Background <p>Family-Centered Empowerment Model (FCEM) is a model which promotes knowledge, and skills which help family members to gain better understanding of the child’s health problems that is consequently reduce care burden level.</p> Aim <p>The current study’ aim was to evaluate the impact of nursing interventions on the care burden experienced by mothers of children with epilepsy: A family Centered empowerment model.</p> Design <p>A quasi experimental design was utilized.</p> Subjects <p>A purposive sample of 60 mothers accompanied their children with epilepsy was involved.</p> Setting <p>This study was carried out at Neurological Unit, Pediatric Medical Department &amp; Neurological Outpatient Clinic of Tanta Main University Hospital.</p> Tools: <p><b>Tool I</b> Epilepsy Knowledge Questionnaire.</p> Tool II <p>Mothers’ Reported Practice Regarding Epilepsy.</p> Tool III <p>Zarit Burden Short Version Interview.</p> Results <p>After implementing FCEM all of the mothers’ showed significant improvement in their knowledge levels, both immediately posttest and at three months follow-up compared to about one third of them who showed adequate knowledge at pre-test. Most of mothers had unsatisfactory practice before implementing FCEM. However, these practice had improved notably for the majority both immediately and after three months post implementing FCEM. There was a significant decrease in mothers’ care burden following implementation of FCEM as compared to pre- implementing FCEM.</p> Conclusion <p>Mothers knowledge and reported practice were improved after implementing FCCM. Implementing family-centered empowerment model had significantly decreased mothers’ care burden of their children with epilepsy.</p> Recommendation <p>Incorporate family-centered empowerment model into routine nursing care for children with epilepsy.</p>