Background <p>The mental health of nurses is deteriorating. Maintaining nurses’ resilience has become a focal point for future nursing development.</p> Objective <p>We aim to rank the effectiveness and acceptability of resilience-focused interventions for nurses.</p> Methods <p>A systematic review and network meta-analysis were conducted, with comprehensive searches across PubMed, Embase, Cochrane Library, Web of Science, and other databases. Frequentist random-effects network meta-analyses were employed, and RoB-2 was used to assess the quality of evidence.</p> Results <p>Resilience-focused interventions were found to significantly enhance nurses’ resilience (95%CI 0.61, 1.41). Offline field interventions (95%CI 0.64, 1.59) outperformed online interventions (95%CI -0.02, 0.45). Both group (95%CI 0.32, 0.87) and individual (95%CI 0.63, 1.59) interventions showed effectiveness. Anger Management Psychoeducation (95%CI 3.65,7.93, SUCRA = 98.2), Emotional Intelligence training (95%CI 3.32,6.51, SUCRA = 95), and Mindfulness-Based Stress Reduction (95%CI 2.60,5.88, SUCRA = 92.4) were the most effective interventions.</p> Conclusion <p>Anger Management Psychoeducation, Mindfulness-Based Stress Reduction, and Emotional Intelligence training are the most effective interventions for enhancing nurses’ resilience.</p> International prospective register of systematic reviews <p>CRD42021289477.</p> Registration of clinical trial and registration identification number <p>Not applicable.</p>