Background <p>A breast cancer diagnosis extends beyond physical health concerns, profoundly impacting a woman’s psychological well-being, resilience and sexual satisfaction. Mastectomy intensifies these challenges, potentially affecting overall quality of life and long-term well-being. Understanding the interrelationships between perceived stress, resilience and sexual satisfaction is crucial for designing targeted interventions that effectively support mastectomized women. This study evaluates the effectiveness of the Emotional Freedom Technique in mitigating stress, enhancing resilience and improving sexual well-being post-mastectomy.</p> Methods <p>A quasi-experimental pretest-posttest design was employed with a convenient sample of 112 Egyptian women who had undergone mastectomy. Participants were recruited from the Outpatient Oncology Clinic at Beni-Suef University Hospital. Data were collected over six months (January–June 2024) and analyzed using SPSS version 26.0. The intervention consisted of six structured EFT sessions delivered over six weeks. Paired t-tests assessed pre- and post-intervention differences, while Pearson and Spearman correlation analyses examined relationships between variables to accommodate different data distributions.</p> Results <p>Post-intervention assessments revealed statistically significant improvements. Perceived stress scores decreased from 32.42 ± 1.70 to 17.27 ± 2.96 (t = 49.130, <i>p</i> &lt; 0.001, Cohen’s d = 3.2), resilience scores increased from 11.53 ± 1.67 to 31.46 ± 5.48 (t = 36.454, <i>p</i> &lt; 0.001, Cohen’s d = 2.8) and sexual satisfaction scores improved from 17.03 ± 1.55 to 31.00 ± 4.31 (t = 13.245, <i>p</i> &lt; 0.001, Cohen’s d = 2.5). Strong negative correlations were found between perceived stress and both resilience (<i>r</i> = -0.692, <i>p</i> &lt; 0.001) and sexual satisfaction (<i>r</i> = -0.835, <i>p</i> &lt; 0.001), while resilience and sexual satisfaction were strongly positively correlated (<i>r</i> = 0.890, <i>p</i> &lt; 0.001).</p> Conclusion <p>EFT is a cost-effective, non-invasive intervention that significantly reduces stress, enhances resilience and improves sexual satisfaction in women post-mastectomy. To optimize clinical integration, healthcare institutions should develop structured EFT training programs for nurses, incorporating theoretical foundations, hands-on practice and competency assessments. Standardized protocols should be established to guide EFT implementation in post-mastectomy care. Further research should explore long-term effects and broader applicability across diverse healthcare settings.</p> Clinical trial number <p>NCT06583629 on 4/9/2024.</p>