Background <p>Recent guidelines in paediatric critical care emphasize the implementation of the evidence-based liberation bundle to improve patient outcomes in paediatric intensive care units (PICUs). However, there is limited information on the application of this bundle in Egyptian hospitals, and the effectiveness of educational programs on nurse performance in this context remains unclear.</p> Aim <p>This study aimed to evaluate the effect of an educational program on nurses’ performance regarding the application of the liberation bundle in paediatric intensive care unit.</p> Methods <p>A one-group pre/post quasi-experimental design was employed. The study was conducted in the PICUs of Al-Azhar University Hospital and Menoufia University Hospital, involving a convenient sample of 52 paediatric nurses. Data were collected using two tools: a predesigned questionnaire to assess knowledge about the liberation bundle and an observational checklist to evaluate nurse practices before and after the educational program.</p> Results <p>The results demonstrated significant improvements in nurses’ knowledge and practices post-intervention. The studied nurses’ total level of knowledge regarding the liberation bundle increased from 13.7 to 92.3% post-educational program X2 (P. value) = 89.143(0.000). The studied nurses’ total level of practices regarding the liberation bundle increased from 9.6 to 80.8% post-educational program X2 (P. value) = 89.143(0.000).</p> Conclusion <p>The educational program significantly enhanced the nurses’ knowledge and practices in applying the liberation bundle in PICUs. This improvement in knowledge and practices is expected to lead to better outcomes for paediatric patients, including reduced mortality, shorter PICU stays, and fewer post-intensive care complications. By equipping nurses with the skills to implement the bundle, the program can improve recovery and long-term health outcomes in critically ill children.</p>