Background <p>Interprofessional education has become increasingly important in preparing dental hygiene students for collaborative healthcare practice. However, despite its growing implementation, comprehensive evidence of the effectiveness of interprofessional education for dental hygiene students remains limited. Therefore, this study conducted a systematic review and synthesized evidence on the educational effects of interprofessional education for dental hygiene students, including impacts on their competencies, attitudes, readiness, knowledge, and satisfaction.</p> Methods <p>A systematic review was conducted following the PRISMA 2020 guidelines. Five electronic databases (MEDLINE, Embase, Cochrane Central Register of Controlled Trials, PubMed, and Scopus) were searched from inception through April 2025 without language restrictions. Studies involving dental hygiene students participating in interprofessional education with measurable outcomes were included. Two reviewers independently screened studies, extracted data, and assessed their quality using appropriate tools. This review was registered in PROSPERO (CRD420251040678).</p> Results <p>Among 888 initially retrieved records, 33 studies published between 1997 and 2025 met the inclusion criteria. Most included studies demonstrated statistically significant effectiveness of interprofessional education. The Readiness for Interprofessional Learning Scale was the most frequently utilized assessment instrument. A meta-analysis of measurements with this scale (<i>n</i> = 275) revealed significant improvement in readiness for interprofessional learning. In contrast, an analysis of measurements using the Interprofessional Socialization and Valuing Scale (<i>n</i> = 104) showed no significant changes in interprofessional socialization. However, the overall evidence should be interpreted cautiously due to the predominance of non-randomized study designs and substantial risk of bias across included studies.</p> Conclusions <p>This systematic review indicates that interprofessional education has the potential to be effective for dental hygiene students. However, the quality of evidence is limited by methodological constraints. These findings support integrating interprofessional education into dental hygiene curricula to enhance preparation for collaborative healthcare practice.</p>