Scholarlink

Background <p>The natural compound cedrol possess anti-inflammatory and antioxidant properties. We sought to assess the neuroprotective effect of cedrol in an animal model of transient global ischemia/reperfusion (I/R) injury.</p> Method <p>To induce transient global cerebral I/R injury, bilateral carotid arteries were temporarily occluded for 20&#xa0;min. A total of 40 male Wistar rats were randomly divided in to 5 groups; The control and global I/R groups, and the treatment groups that received cedrol at doses of 7.5, 15, and 30&#xa0;mg/kg/day for a week, following the global I/R induction. The passive avoidance test was used for assessing memory function, and then hippocampal tissues were collected to assess levels of malondialdehyde (MDA), total thiol, nitric oxide (NO), and the activity of superoxide dismutase (SOD), along with the concentration of brain-derived neurotrophic factor (BDNF).</p> Result <p>Our findings revealed that global I/R injury impaired rats’ performance in the passive avoidance test and increased levels of MDA and NO. Moreover, it decreased the total thiol level, SOD activity, and BDNF level in the hippocampus. Administration of cedrol significantly improved memory function, reduced oxidative stress, NO level and increased BDNF level in the hippocampus.</p> Conclusion <p>The results indicate that cedrol has neuroprotective properties in global I/R by reducing oxidative stress and enhancing the levels of BDNF.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Protective effects of cedrol against transient global cerebral ischemia/reperfusion injury in rat

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年2月26日

查看全文
  • Samira Asgharzade,
  • Amir Mahmoud Ahmadzadeh,
  • Ali Mohammad Pourbagher-Shahri,
  • Fatemeh Forouzanfar

摘要

Background

The natural compound cedrol possess anti-inflammatory and antioxidant properties. We sought to assess the neuroprotective effect of cedrol in an animal model of transient global ischemia/reperfusion (I/R) injury.

Method

To induce transient global cerebral I/R injury, bilateral carotid arteries were temporarily occluded for 20 min. A total of 40 male Wistar rats were randomly divided in to 5 groups; The control and global I/R groups, and the treatment groups that received cedrol at doses of 7.5, 15, and 30 mg/kg/day for a week, following the global I/R induction. The passive avoidance test was used for assessing memory function, and then hippocampal tissues were collected to assess levels of malondialdehyde (MDA), total thiol, nitric oxide (NO), and the activity of superoxide dismutase (SOD), along with the concentration of brain-derived neurotrophic factor (BDNF).

Result

Our findings revealed that global I/R injury impaired rats’ performance in the passive avoidance test and increased levels of MDA and NO. Moreover, it decreased the total thiol level, SOD activity, and BDNF level in the hippocampus. Administration of cedrol significantly improved memory function, reduced oxidative stress, NO level and increased BDNF level in the hippocampus.

Conclusion

The results indicate that cedrol has neuroprotective properties in global I/R by reducing oxidative stress and enhancing the levels of BDNF.