Background <p>PCOS is a complex health condition that affects up to 20% females of reproductive age worldwide, and approximately 5 million U.S. females of reproductive aged females. Despite the prevalence of the condition, research on the lived experiences of women with PCOS is limited, particularly in the United States.</p> Methods <p>This study employed a phenomenological qualitative design to explore the lived experiences of individuals diagnosed with PCOS. We conducted semi-structured interviews via web conferencing with 39 females 18–45&#xa0;years of age, residing in the U.S. with PCOS. Transcribed interviews were analyzed using the Framework Method.</p> Results <p>We identified ten primary themes in the data 1) Critical shift point, 2) Education, 3) Future Experience, 4) Gaslighting (or blame), 5) Medical Experience, 6) Present Emotional Experience, 7) Social Impacts, 8) Treatment, 9) Well-documented Physical Symptoms, and 10) Not Well-Documented Symptoms and an additional 37 sub-themes. Overall, the experiences of living with PCOS were generally negative, especially in relation to gaslighting or blame, medical experience, symptoms – both well documented and not well documented, present emotional experience, social impacts, and treatment. Additionally, many participants reported a critical shift point that led to them seeking a diagnosis and treatment for their condition, and a lack of education in relation to PCOS.</p> Conclusions <p>Women with PCOS experience a wide-ranging physical, mental, and relational impacts. Awareness of the impact of PCOS is needed to reduce gaps in provider knowledge, social disconnect, fear of judgment, and mental health concerns. Further research is needed to understand the impact of PCOS on the lived experience of post-menopausal women, and to develop improved education for both providers and those in the social circle of women with PCOS.</p>