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Background <p>Endometriosis of the canal of Nuck is an extremely rare manifestation of extrapelvic endometriosis that may mimic common groin pathologies such as inguinal hernia or hydrocele, often leading to diagnostic difficulty and delayed recognition.</p> Case Presentation <p>We report the case of a 29-year-old nulliparous woman who presented with a gradually enlarging painless swelling in the right vulvar region over eight months. Physical examination revealed a large cystic mass measuring approximately 15 × 10&#xa0;cm involving the right vulva and inguinal area with displacement of the clitoris and vaginal introitus. Ultrasonography demonstrated a well-defined cystic lesion with internal echoes, while magnetic resonance imaging revealed a hemorrhagic cystic lesion along the course of the canal of Nuck without peritoneal communication. Surgical exploration identified a cystic mass adjacent to the round ligament containing characteristic “chocolate-like” fluid. Complete excision of the lesion was performed. Histopathological examination confirmed endometrioma of the canal of Nuck. The postoperative course was uneventful, and the patient remained asymptomatic with no evidence of recurrence during a 3-year follow-up.</p> Conclusion <p>Although rare, canal of Nuck endometriosis should be considered in the differential diagnosis of inguinal or vulvar masses in women of reproductive age. Early recognition, appropriate imaging and complete surgical excision allow accurate diagnosis and excellent outcomes. This case highlights an unusually large presentation and emphasises the diagnostic challenges associated with atypical clinical features.</p>

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Giant endometrioma of the canal of nuck mimicking a vulvar mass: a rare case and narrative review

  • 期刊论文

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  • 发表日期：

    2026年5月14日

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  • Lateefa O. Aldakhil

摘要

Background

Endometriosis of the canal of Nuck is an extremely rare manifestation of extrapelvic endometriosis that may mimic common groin pathologies such as inguinal hernia or hydrocele, often leading to diagnostic difficulty and delayed recognition.

Case Presentation

We report the case of a 29-year-old nulliparous woman who presented with a gradually enlarging painless swelling in the right vulvar region over eight months. Physical examination revealed a large cystic mass measuring approximately 15 × 10 cm involving the right vulva and inguinal area with displacement of the clitoris and vaginal introitus. Ultrasonography demonstrated a well-defined cystic lesion with internal echoes, while magnetic resonance imaging revealed a hemorrhagic cystic lesion along the course of the canal of Nuck without peritoneal communication. Surgical exploration identified a cystic mass adjacent to the round ligament containing characteristic “chocolate-like” fluid. Complete excision of the lesion was performed. Histopathological examination confirmed endometrioma of the canal of Nuck. The postoperative course was uneventful, and the patient remained asymptomatic with no evidence of recurrence during a 3-year follow-up.

Conclusion

Although rare, canal of Nuck endometriosis should be considered in the differential diagnosis of inguinal or vulvar masses in women of reproductive age. Early recognition, appropriate imaging and complete surgical excision allow accurate diagnosis and excellent outcomes. This case highlights an unusually large presentation and emphasises the diagnostic challenges associated with atypical clinical features.