Scholarlink

Background <p>We developed novel Optimized Nutri-Dense Meals (Opti meals) for women based on Japanese dietary reference intakes (DRIs). We aimed to determine the effects of Opti meals on premenstrual disorder (PMD).</p> Method <p>This pilot study was an open-label randomized controlled trial. One hundred women aged 20–45&#xa0;years with PMD were enrolled in the study and randomly divided into two groups: habitual diet and intervention groups. In the intervention group, two meals per day for three menstrual cycles were replaced with Opti meals based on the Japanese DRIs. The Menstrual Distress Questionnaire (MDQ) and the Japanese version of the Daily Records of Severity of Problems Short-Form version (J-DRSP) served as the primary outcome measures. Sleep quality and several saliva and serum parameters were set as secondary outcomes.</p> Result <p>The intervention group had lower MDQ total scores during the premenstrual (median [Q1–Q3]: 42.0 [23.8–64.0] versus 67.0 [44.0–90.5], <i>p</i> &lt; 0.01) and menstrual (34.0 [23.0–53.0] versus 67.0 [35.0–76.5], <i>p</i> &lt; 0.01) phases, as well as lower final J-DRSP total scores (17.25 [13.73–19.90] versus 22.0 [16.60–28.50], <i>p</i> &lt; 0.01) than the habitual diet group.</p> <p>Some significant differences were observed in the sleep quality test; however, no significant differences were found in saliva or serum parameters at the end of the trial.</p> Conclusion <p>Optimal meals based on the Japanese DRI may improve PMD symptoms.</p> Trial registration <p>UMIN000052973, <a href="https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000060324">https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000060324</a> (3/12/2023).</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Novel dietary FemTech based on dietary reference intakes for premenstrual and menstrual disorders: a pilot open-label randomized controlled trial of dietary intervention

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年3月9日

查看全文
  • Jun Iimura,
  • Naohisa Shobako,
  • Masahiro Yagibashi,
  • Atsushi Nakajima,
  • Shintaro Fujii,
  • Takuo Nakazeko,
  • Yukio Hirano,
  • Futoshi Nakamura,
  • Keiko Honda

摘要

Background

We developed novel Optimized Nutri-Dense Meals (Opti meals) for women based on Japanese dietary reference intakes (DRIs). We aimed to determine the effects of Opti meals on premenstrual disorder (PMD).

Method

This pilot study was an open-label randomized controlled trial. One hundred women aged 20–45 years with PMD were enrolled in the study and randomly divided into two groups: habitual diet and intervention groups. In the intervention group, two meals per day for three menstrual cycles were replaced with Opti meals based on the Japanese DRIs. The Menstrual Distress Questionnaire (MDQ) and the Japanese version of the Daily Records of Severity of Problems Short-Form version (J-DRSP) served as the primary outcome measures. Sleep quality and several saliva and serum parameters were set as secondary outcomes.

Result

The intervention group had lower MDQ total scores during the premenstrual (median [Q1–Q3]: 42.0 [23.8–64.0] versus 67.0 [44.0–90.5], p < 0.01) and menstrual (34.0 [23.0–53.0] versus 67.0 [35.0–76.5], p < 0.01) phases, as well as lower final J-DRSP total scores (17.25 [13.73–19.90] versus 22.0 [16.60–28.50], p < 0.01) than the habitual diet group.

Some significant differences were observed in the sleep quality test; however, no significant differences were found in saliva or serum parameters at the end of the trial.

Conclusion

Optimal meals based on the Japanese DRI may improve PMD symptoms.

Trial registration

UMIN000052973, https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000060324 (3/12/2023).