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Background <p>This study explored Nectin-4 expression in endometrial adenocarcinoma and examined its relationship with tumor grade, hormone receptor status, p53 expression, and mismatch repair (MMR) protein expression.</p> Methods <p>We retrospectively analyzed 55 paraffin-embedded tissue samples collected between 2015 and 2023, including endometrial adenocarcinoma, endometrial intraepithelial neoplasia (EIN), and normal endometrium samples. Nectin-4 expression was assessed via immunohistochemistry, and correlations with clinicopathological features and molecular markers were evaluated statistically.</p> Results <p>Nectin-4 expression increased with histological grade (<i>p</i> &lt; 0.001). All Grade III tumors presented strong expression, whereas lower-grade tumors presented variable staining. The expression of these genes was also correlated with p53 overexpression (<i>p</i> = 0.007) and PMS2 loss (<i>p</i> = 0.002). Nectin-4 was absent in normal tissues and weakly expressed in EIN.</p> Conclusion <p>Nectin-4 expression is linked to high-grade endometrial carcinoma and abnormal p53 expression, supporting its potential role as a diagnostic biomarker. Larger studies are needed to validate its clinical use.</p>

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Exploring Nectin-4 as a potential diagnostic biomarker in endometrial adenocarcinoma

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年12月19日

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  • Melike Ordu,
  • Serife Ozlem Genc

摘要

Background

This study explored Nectin-4 expression in endometrial adenocarcinoma and examined its relationship with tumor grade, hormone receptor status, p53 expression, and mismatch repair (MMR) protein expression.

Methods

We retrospectively analyzed 55 paraffin-embedded tissue samples collected between 2015 and 2023, including endometrial adenocarcinoma, endometrial intraepithelial neoplasia (EIN), and normal endometrium samples. Nectin-4 expression was assessed via immunohistochemistry, and correlations with clinicopathological features and molecular markers were evaluated statistically.

Results

Nectin-4 expression increased with histological grade (p < 0.001). All Grade III tumors presented strong expression, whereas lower-grade tumors presented variable staining. The expression of these genes was also correlated with p53 overexpression (p = 0.007) and PMS2 loss (p = 0.002). Nectin-4 was absent in normal tissues and weakly expressed in EIN.

Conclusion

Nectin-4 expression is linked to high-grade endometrial carcinoma and abnormal p53 expression, supporting its potential role as a diagnostic biomarker. Larger studies are needed to validate its clinical use.