Scholarlink

Background <p>The menopausal transition, a critical period for midlife women’s health, is marked by visceral fat redistribution. Although obesity and diabetes share common risk factors, their independent contributions to health risk remain unclear. This study investigated the association between 10-year mean waist circumference (WC) and incident type 2 diabetes in premenopausal women, and evaluated the impact of shared risk factors on both measures.</p> Methods <p>Using data from a community-based cohort with 16 years of follow-up, 1,482 premenopausal women at baseline were analyzed. The mean WC over 10 years was assessed, and its impact on incident type 2 diabetes over the subsequent six years was evaluated using Cox proportional models and visualized via mixed graphical model. Numerous demographics, lifestyle, genetic, and metabolic factors were considered shared risk factors.</p> Results <p>Over 10 years, WC increased by 0.22&#xa0;cm annually (mean WC 78.3&#xa0;cm). In the subsequent six years, 88 new cases of type 2 diabetes were identified. The mean WC varied with age, study area, education level, parental diabetes, alcohol consumption, and metabolic factors. Additionally, each 1&#xa0;cm increase in the mean WC raised type 2 diabetes risk by 8% (95% CI: 1.05–1.11). Genetic factors; current smoking; and baseline metabolic factors were also independently associated with type 2 diabetes risk. This association persisted in women who transitioned to menopause during follow-up.</p> Conclusions <p>The association between higher WC during the menopausal transition and type 2 diabetes risk was observed. Comprehensive interventions aimed at lowering abdominal obesity could help reduce the risk of type 2 diabetes.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Long-term waist circumference and diabetes risk in premenopausal women: role of shared risk factors

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年11月3日

查看全文
  • Hye Ah Lee

摘要

Background

The menopausal transition, a critical period for midlife women’s health, is marked by visceral fat redistribution. Although obesity and diabetes share common risk factors, their independent contributions to health risk remain unclear. This study investigated the association between 10-year mean waist circumference (WC) and incident type 2 diabetes in premenopausal women, and evaluated the impact of shared risk factors on both measures.

Methods

Using data from a community-based cohort with 16 years of follow-up, 1,482 premenopausal women at baseline were analyzed. The mean WC over 10 years was assessed, and its impact on incident type 2 diabetes over the subsequent six years was evaluated using Cox proportional models and visualized via mixed graphical model. Numerous demographics, lifestyle, genetic, and metabolic factors were considered shared risk factors.

Results

Over 10 years, WC increased by 0.22 cm annually (mean WC 78.3 cm). In the subsequent six years, 88 new cases of type 2 diabetes were identified. The mean WC varied with age, study area, education level, parental diabetes, alcohol consumption, and metabolic factors. Additionally, each 1 cm increase in the mean WC raised type 2 diabetes risk by 8% (95% CI: 1.05–1.11). Genetic factors; current smoking; and baseline metabolic factors were also independently associated with type 2 diabetes risk. This association persisted in women who transitioned to menopause during follow-up.

Conclusions

The association between higher WC during the menopausal transition and type 2 diabetes risk was observed. Comprehensive interventions aimed at lowering abdominal obesity could help reduce the risk of type 2 diabetes.