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Objectives <p>the aim of this study was to evaluate the impact of <i>TLR4</i> gene single nucleotide polymorphisms (SNPs) and additional <i>TLR4</i> gene SNP- SNP and SNP- abdominal obesity (AO) interaction on ovarian cancer (OC) risk.</p> Methods <p>Generalized multifactor dimensionality reduction method were utilized to identify the most informative interactions between four SNPs in the <i>TLR4</i> gene and abdominal obesity. Logistic regression was employed to investigate the association between 4 SNPs within <i>TLR4</i> gene and OC risk, and additional SNP- SNP and gene- AO interaction on OC risk, ORs (95%CI) were calculated.</p> Results <p>The analysis of logistic regression indicated a markedly elevated risk of OC in individuals carrying either the rs4986790-G or rs11536889-C alleles in the <i>TLR4</i> gene compared to those with the standard genetic variations, adjusted ORs (95%CI) were 1.61 (1.28–1.96) and 1.48 (1.09–1.91). GMDR analysis indicated a significant two-locus model (<i>p</i> = 0.018) involving rs4986790 and rs11536889, and a significant two-locus model (<i>p</i> = 0.001) involving rs4986790 and AO. Participants with rs4986790- AG/GG and rs11536889GC/ CC genotype has the highest OC risk, compared to participants with rs4986790-AA and rs11536889-GG genotype, OR (95%CI) = 2.58 (1.46–3.71), and abdominal obese participants with rs4986790- AG/GG genotype have the highest OC risk, compared to non- abdominal obese participants with rs4986790-AA genotype, OR (95%CI) = 3.17 (1.78–4.58).</p> Conclusions <p>The findings suggested that <i>TLR4</i> gene rs4986790 and rs11536889 polymorphisms were associated with increased OC risk. Significant interaction also existed between rs4986790 and AO, which means that the WC levels may influence the impact of rs4986790 on OC risk.</p>

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Interaction between toll-like receptor 4 polymorphism and abdominal obesity on ovarian cancer risk in Chinese women

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年9月29日

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  • Jiamin Zhu,
  • Baixia Yang,
  • Xiaogang Zhai,
  • Feng Ni,
  • Dan Tao,
  • Cheng Tan

摘要

Objectives

the aim of this study was to evaluate the impact of TLR4 gene single nucleotide polymorphisms (SNPs) and additional TLR4 gene SNP- SNP and SNP- abdominal obesity (AO) interaction on ovarian cancer (OC) risk.

Methods

Generalized multifactor dimensionality reduction method were utilized to identify the most informative interactions between four SNPs in the TLR4 gene and abdominal obesity. Logistic regression was employed to investigate the association between 4 SNPs within TLR4 gene and OC risk, and additional SNP- SNP and gene- AO interaction on OC risk, ORs (95%CI) were calculated.

Results

The analysis of logistic regression indicated a markedly elevated risk of OC in individuals carrying either the rs4986790-G or rs11536889-C alleles in the TLR4 gene compared to those with the standard genetic variations, adjusted ORs (95%CI) were 1.61 (1.28–1.96) and 1.48 (1.09–1.91). GMDR analysis indicated a significant two-locus model (p = 0.018) involving rs4986790 and rs11536889, and a significant two-locus model (p = 0.001) involving rs4986790 and AO. Participants with rs4986790- AG/GG and rs11536889GC/ CC genotype has the highest OC risk, compared to participants with rs4986790-AA and rs11536889-GG genotype, OR (95%CI) = 2.58 (1.46–3.71), and abdominal obese participants with rs4986790- AG/GG genotype have the highest OC risk, compared to non- abdominal obese participants with rs4986790-AA genotype, OR (95%CI) = 3.17 (1.78–4.58).

Conclusions

The findings suggested that TLR4 gene rs4986790 and rs11536889 polymorphisms were associated with increased OC risk. Significant interaction also existed between rs4986790 and AO, which means that the WC levels may influence the impact of rs4986790 on OC risk.