Background <p>Endometriosis is a chronic gynecological disease that affects various aspects of the women’s lives, so considering its impacts and improving health-promoting lifestyle is important. The present study aimed to determine the association between health-promoting lifestyle and endometriosis impacts on women lives.</p> Methods <p>This cross-sectional study was conducted on 200 women with endometriosis in the endometriosis clinic of Imam Reza Hospital in Mashhad-Iran. The data was collected using the HPLP-II (health-promoting lifestyle) and EIQ tools (endometriosis impact questionnaire), as well as socio-demographic and obstetrics characteristics questionnaires. Data was analyzed in SPSS 21 software. Spearman’s test was used to investigate the correlation between health-promoting behaviors and the impacts of endometriosis on women’s lives.</p> Results <p>In the total of three recall periods of EIQ, there was a negative significant correlation between the overall lifestyle score of HPLP and the physical impact of endometriosis disease (<i>r</i>=-0.23; <i>P</i> &lt; 0.001), the psychological impact (<i>r</i>=-0.29; <i>P</i> &lt; 0.001), social impact (<i>r</i>=-0.30; <i>P</i> &lt; 0.001), as well as education dimensions of EIQ (<i>r</i>=-0.52; <i>P</i> = 0.016).</p> Conclusions <p>Considering the negative significant correlation between the health-promoting lifestyle and the physical, psychological, social, as well as education impacts of endometriosis, adopting a healthy lifestyle for women with endometriosis seems useful and necessary. In future studies, it is recommended to provide information for writing a program with a clear and concise explanation for these women to improve affected women’s lives.</p>