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Background <p>To synthesize evidence from systematic reviews and meta-analyses on low-level laser therapy/Photobiomodulation (LLLT/PBM) and vitamin D as non-invasive adjuncts for accelerating orthodontic tooth movement (OTM) and mitigating associated side effects.</p> Methods <p>PubMed/MEDLINE, Embase, Scopus, Web of Science, and Cochrane Library databases were searched from inception to November 18, 2025. SRMAs primarily comprising human RCTs evaluating LLLT/PBM or vitamin D in orthodontics were included; in some mixed-design reviews, clearly separable human orthodontic data from a small number of CCTs were retained narratively. (one pre-registered exception with 4 RCTs for vitamin D to ensure completeness). Randomized controlled trials were prioritized; some retained reviews also included a small number of controlled clinical trials when relevant human orthodontic data were clearly separable. Quality was assessed using AMSTAR-2, ROBIS, and GRADE. Narrative synthesis was performed because of high heterogeneity.</p> Results <p>Twenty systematic reviews and meta-analyses covering a large number of human orthodontic trials were included. Low-certainty evidence suggests that LLLT/PBM may be associated with accelerated OTM, slight reductions in orthodontically induced inflammatory root resorption (OIIRR), and short-term pain relief. Vitamin D showed inconsistent findings across outcomes with no reliable overall clinical benefit.</p> Conclusions <p>Current evidence is insufficient to recommend the routine clinical use of LLLT/PBM or vitamin D in orthodontics.</p> Trial Registration <p>PROSPERO CRD42024591253.</p>

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Umbrella review of photobiomodulation/low-level laser therapy and vitamin D in orthodontics: effects on tooth movement, pain, root resorption, and bone biomarkers

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月16日

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  • Syed Abid Altaf Bukhari,
  • Ahmad Hashridz Bin Ruslan,
  • Rozita Hassan

摘要

Background

To synthesize evidence from systematic reviews and meta-analyses on low-level laser therapy/Photobiomodulation (LLLT/PBM) and vitamin D as non-invasive adjuncts for accelerating orthodontic tooth movement (OTM) and mitigating associated side effects.

Methods

PubMed/MEDLINE, Embase, Scopus, Web of Science, and Cochrane Library databases were searched from inception to November 18, 2025. SRMAs primarily comprising human RCTs evaluating LLLT/PBM or vitamin D in orthodontics were included; in some mixed-design reviews, clearly separable human orthodontic data from a small number of CCTs were retained narratively. (one pre-registered exception with 4 RCTs for vitamin D to ensure completeness). Randomized controlled trials were prioritized; some retained reviews also included a small number of controlled clinical trials when relevant human orthodontic data were clearly separable. Quality was assessed using AMSTAR-2, ROBIS, and GRADE. Narrative synthesis was performed because of high heterogeneity.

Results

Twenty systematic reviews and meta-analyses covering a large number of human orthodontic trials were included. Low-certainty evidence suggests that LLLT/PBM may be associated with accelerated OTM, slight reductions in orthodontically induced inflammatory root resorption (OIIRR), and short-term pain relief. Vitamin D showed inconsistent findings across outcomes with no reliable overall clinical benefit.

Conclusions

Current evidence is insufficient to recommend the routine clinical use of LLLT/PBM or vitamin D in orthodontics.

Trial Registration

PROSPERO CRD42024591253.