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Purpose <p>This study aimed to determine the antibacterial efficacy of sodium dichloro-iso-cyanurate (NaDCC) compared to double antibiotic paste (DAP) and calcium hydroxide (CH) against Enterococcus faecalis (E. faecalis).</p> Methods <p>The study utilized a sample of forty-four human single-rooted teeth, which were decoronated and chemo-mechanically prepared. E. faecalis was then inoculated into the teeth for four weeks. The samples were randomly divided into four groups, each receiving a different intracanal medicament: DAP (<InlineEquation ID="IEq1"><EquationSource Format="TEX">\(n = 12\)</EquationSource></InlineEquation>), NaDCC (<InlineEquation ID="IEq2"><EquationSource Format="TEX">\(n = 12\)</EquationSource></InlineEquation>), CH (<InlineEquation ID="IEq3"><EquationSource Format="TEX">\(n = 12\)</EquationSource></InlineEquation>), and a control group treated with sterile water (<InlineEquation ID="IEq4"><EquationSource Format="TEX">\(n = 6\)</EquationSource></InlineEquation>). After a contact time of 28 days, a sample was taken from each root canal with a paper point. The number of colony-forming units was then calculated, and data analysis was performed using Kruskal Wallis and Mann-Whitney tests.</p> Results <p>All the medicaments had a significantly higher antibacterial effect than the control group (<InlineEquation ID="IEq5"><EquationSource Format="TEX">\(p-value &lt; 0.05\)</EquationSource></InlineEquation>). DAP showed a significantly higher antibacterial effect than NaDCC (<InlineEquation ID="IEq6"><EquationSource Format="TEX">\(p-value &lt; 0.01\)</EquationSource></InlineEquation>) and CH (<InlineEquation ID="IEq7"><EquationSource Format="TEX">\(p-value &lt; 0.01\)</EquationSource></InlineEquation>). NaDCC showed a significantly higher antibacterial effect than CH (<InlineEquation ID="IEq8"><EquationSource Format="TEX">\(p-value &lt; 0.01\)</EquationSource></InlineEquation>).</p> Conclusion <p>The study’s results indicate that DAP is the most effective medicament against E. faecalis. However, the study also revealed that NaDCC, a relatively novel substance in endodontics, demonstrated a higher antibacterial efficacy than CH. This suggests that NaDCC could be a promising addition to the range of medicaments used in regenerative procedures.</p>

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Comparison of the biocidal efficacy of sodium dichloro-iso-cyanurate, double antibiotic pastes and calcium hydroxide as intra-canal medicaments for regenerative endodontic therapy: an ex-vivo study

  • 期刊论文

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  • 发表日期：

    2026年7月13日

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  • Alireza Adl,
  • Fereshte Sobhnamayan,
  • Mohammad Motamedifar,
  • Mohammad mehdi Shokouhi,
  • Amir hossein Ghadri,
  • Samina Gavahianjahromi

摘要

Purpose

This study aimed to determine the antibacterial efficacy of sodium dichloro-iso-cyanurate (NaDCC) compared to double antibiotic paste (DAP) and calcium hydroxide (CH) against Enterococcus faecalis (E. faecalis).

Methods

The study utilized a sample of forty-four human single-rooted teeth, which were decoronated and chemo-mechanically prepared. E. faecalis was then inoculated into the teeth for four weeks. The samples were randomly divided into four groups, each receiving a different intracanal medicament: DAP (\(n = 12\)), NaDCC (\(n = 12\)), CH (\(n = 12\)), and a control group treated with sterile water (\(n = 6\)). After a contact time of 28 days, a sample was taken from each root canal with a paper point. The number of colony-forming units was then calculated, and data analysis was performed using Kruskal Wallis and Mann-Whitney tests.

Results

All the medicaments had a significantly higher antibacterial effect than the control group (\(p-value < 0.05\)). DAP showed a significantly higher antibacterial effect than NaDCC (\(p-value < 0.01\)) and CH (\(p-value < 0.01\)). NaDCC showed a significantly higher antibacterial effect than CH (\(p-value < 0.01\)).

Conclusion

The study’s results indicate that DAP is the most effective medicament against E. faecalis. However, the study also revealed that NaDCC, a relatively novel substance in endodontics, demonstrated a higher antibacterial efficacy than CH. This suggests that NaDCC could be a promising addition to the range of medicaments used in regenerative procedures.