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Background <p>Diabetes mellitus has been associated with an increased incidence and potentially with a worse prognosis of squamous cell carcinomas due to chronic inflammation, oxidative stress, and metabolic reprogramming, which promote tumor growth and therapy resistance. Furthermore, it impairs immune response and posttreatment healing, potentially leading to higher complication rates.</p> Methods <p>The study protocol was preregistered (CRD42025634653). An electronic search was conducted in MEDLINE, Embase, and Cochrane. Studies on patients with squamous cell carcinomas were included to compare survival metrics and complication rates with and without diabetes. Hazard ratios, odds ratios, and mean differences were extracted. A random-effects model was used, with subgroups based on cancer location.</p> Results <p>63 predominantly retrospective studies met the inclusion criteria, with a population of 138,000 individuals. The meta-analysis found statistically significant differences in disease-specific (HR = 1.47 [1.11–1.96]; I<sup>2</sup> = 60%), overall (HR = 1.31 [1.23–1.39]; I<sup>2</sup> = 4%), and disease-free survival (HR = 1.58 [1.12–2.24]; I<sup>2</sup> = 58%); the subgroup analysis revealed that diabetes significantly affected oral and oropharyngeal subsites. Posttreatment stroke (HR = 2.11 [1.15–3.87]; I<sup>2</sup> = 70%) and osteoradionecrosis rates (HR = 2.2 [1.38–3.53]; I<sup>2</sup> = 11%) were significantly elevated.</p> Conclusion <p>Diabetes is associated with worse disease-specific survival in oral and oropharyngeal subtypes and a twofold higher risk of osteoradionecrosis development in patients with squamous cell carcinoma. Weaker evidence suggests that overall survival and stroke development rate are also affected by diabetes mellitus.</p>

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Diabetes is associated with elevated mortality, stroke, and osteoradionecrosis in squamous cell carcinomas of the head and neck: a systematic review and meta-analysis

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年4月22日

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  • Bulcsú Bencze,
  • Bianca Golzio Navarro Cavalcante,
  • Virág Róna,
  • Bence Szabó,
  • Alexander Schulze Wenning,
  • Péter Hermann,
  • Gábor Varga,
  • Orsolya Németh,
  • Péter Hegyi,
  • Dániel Végh

摘要

Background

Diabetes mellitus has been associated with an increased incidence and potentially with a worse prognosis of squamous cell carcinomas due to chronic inflammation, oxidative stress, and metabolic reprogramming, which promote tumor growth and therapy resistance. Furthermore, it impairs immune response and posttreatment healing, potentially leading to higher complication rates.

Methods

The study protocol was preregistered (CRD42025634653). An electronic search was conducted in MEDLINE, Embase, and Cochrane. Studies on patients with squamous cell carcinomas were included to compare survival metrics and complication rates with and without diabetes. Hazard ratios, odds ratios, and mean differences were extracted. A random-effects model was used, with subgroups based on cancer location.

Results

63 predominantly retrospective studies met the inclusion criteria, with a population of 138,000 individuals. The meta-analysis found statistically significant differences in disease-specific (HR = 1.47 [1.11–1.96]; I2 = 60%), overall (HR = 1.31 [1.23–1.39]; I2 = 4%), and disease-free survival (HR = 1.58 [1.12–2.24]; I2 = 58%); the subgroup analysis revealed that diabetes significantly affected oral and oropharyngeal subsites. Posttreatment stroke (HR = 2.11 [1.15–3.87]; I2 = 70%) and osteoradionecrosis rates (HR = 2.2 [1.38–3.53]; I2 = 11%) were significantly elevated.

Conclusion

Diabetes is associated with worse disease-specific survival in oral and oropharyngeal subtypes and a twofold higher risk of osteoradionecrosis development in patients with squamous cell carcinoma. Weaker evidence suggests that overall survival and stroke development rate are also affected by diabetes mellitus.