Background <p>Given the limited evidence regarding the blending performance of single-shade resin composites with ceramic materials, this study aimed to investigate whether a single-shade resin composite can achieve superior color blending with hybrid ceramics compared to conventional multi-shade resin composites.</p> Methods <p>Omnichroma (OM) was used as the single-shade resin composite, while Filtek Z250 (FI), Estelite Σ Quick (ES), and Ceram X SphereTEC One (CE) in A1–A4 shades served as multi-shade resin composites. Amber Mill in A1–A3.5 shades were selected for hybrid ceramic blocks. The experiment was conducted in two phases: (1) the multi-shade resin composite shade most closely matching OM was determined using spectrophotometric color coordinate analysis, and (2) cavities in hybrid ceramic blocks were filled with OM and the selected multi-shade resin composites. The color differences (ΔE₀₀) between the resin composites and hybrid ceramics were measured, and the translucency parameters of the resin composites were evaluated. Statistical comparisons were performed using one-way and two-way ANOVA and Bonferroni test for post-hoc analysis (α = 0.05). Additionally, the filler morphology of the resin composites was examined using scanning electron microscopy (SEM).</p> Results <p>A3 shade exhibited the smallest color difference (ΔE₀₀) from OM across all multi-shade resin composites. OM exhibited significantly lower ΔE₀₀ values (range: 5.7–7.8) across all hybrid ceramic shades compared to the multi-shade resin composites (<i>p</i> &lt; 0.05). Spectrophotometric analysis confirmed that OM’s individual color coordinates (L*, a*, and b*) were closer to those of the hybrid ceramics. Additionally, OM showed the highest translucency among the tested resins (<i>p</i> &lt; 0.05), reinforcing the correlation between translucency and blending performance. SEM revealed differences in filler morphology across resin composites. OM contained uniformly distributed 260&#xa0;nm spherical fillers. ES exhibited smaller (~ 160&#xa0;nm) spherical fillers, while FI and CE showed a heterogeneous distribution of filler sizes with clustering.</p> Conclusions <p>The single-shade resin composite demonstrated a relatively enhanced color blending effect with hybrid ceramics compared to multi-shade resin composites. However, as all ΔE₀₀ values exceeded established clinical acceptability thresholds, the findings reflect relative differences in optical behavior rather than clinically imperceptible color matching.</p>