Background <p>Understanding the properties of dual-cure resin cements is essential for ensuring clinical success. The present study compared the pH, solubility, and radiopacity of the dual-cure resin cements NX3 Nexus^® and Variolink N^®.</p> Methods <p>This in vitro experimental study prepared 30 standardized dual-cure resin cement discs (8&#xa0;mm diameter × 1&#xa0;mm thickness). Discs were equally allocated to two groups (<i>n</i> = 15) —NX3 Nexus^® and Variolink N^®— and, within each cement, randomly assigned to three subgroups for pH, solubility, and radiopacity testing (<i>n</i> = 5 per subgroup). The non-parametric Mann–Whitney U test was employed for comparisons of solubility and pH, while the parametric Student’s t-test was employed for radiopacity. A significance level of <i>p</i> &lt; 0.05 was considered.</p> Results <p>Significant differences were observed between NX3 Nexus and Variolink N when comparing pH (<i>p</i> = 0.008) and radiopacity (<i>p</i> = 0.026). Both resin cements showed no differences when comparing solubility (<i>p</i> = 0.841).</p> Conclusion <p>Under the present in vitro conditions, NX3 Nexus^® and Variolink N^® demonstrated low solubility and comparable pH. Variolink N^®’s higher radiopacity may aid radiographic detection of excess cement and marginal assessment; thus, it may be preferred when radiographic evaluation is critical, whereas either cement is appropriate otherwise.</p>