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Background <p>While the role of oral microbial dysbiosis in cariogenicity is widely appreciated, it remains unclear whether some resident microorganisms are active contributors in this process. Recently, increasing evidence showed that <i>Prevotella</i> spp. are associated with caries whereas the identified roles at species level remain undefined. This study aimed to analyze the effects of <i>Prevotella denticola</i> on microbial ecosystems and pathogenic mechanisms associated with caries.</p> Methods <p>Here, we applied metagenomics to supragingival microbiota (dental plaque) samples from 62 adults to identify disease-relevant species. <i>P. denticola</i> was highly enriched in caries-affected individuals (<i>P</i> &lt; 0.001). The dynamic biofilm formation, spatial arrangement, and cariogenic activity of oral biofilms with or without <i>P. denticola</i> were examined <i>via</i> multiscale/computational imaging and virulence assays.</p> Results <p><i>P. denticola</i>, exerting a previously unidentified mechanism in supragingival biofilms, promoted oral biofilm cariogenicity through altering the microbial ecosystem and biofilm structure. In vivo studies demonstrated that <i>P. denticola</i> induced the formation of a more cariogenic biofilm on supragingival tooth surfaces.</p> Conclusions <p>Collectively, <i>P. denticola</i> has an ecological impact on the mixed oral microbiota and disrupts microbial equilibrium. These findings indicated that <i>P. denticola</i> infection plays a critical role in caries occurrence.</p>

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Prevotella denticola promotes caries by inducing oral microbial dysbiosis

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年2月16日

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  • Haoze Wu,
  • Na Li,
  • Sirui Yang,
  • Jun Qiu,
  • Mai Zhang,
  • Luoqianhui Wang,
  • Rong Gao,
  • Luyao Wu,
  • Qing Yu,
  • Xiaogang Cheng

摘要

Background

While the role of oral microbial dysbiosis in cariogenicity is widely appreciated, it remains unclear whether some resident microorganisms are active contributors in this process. Recently, increasing evidence showed that Prevotella spp. are associated with caries whereas the identified roles at species level remain undefined. This study aimed to analyze the effects of Prevotella denticola on microbial ecosystems and pathogenic mechanisms associated with caries.

Methods

Here, we applied metagenomics to supragingival microbiota (dental plaque) samples from 62 adults to identify disease-relevant species. P. denticola was highly enriched in caries-affected individuals (P < 0.001). The dynamic biofilm formation, spatial arrangement, and cariogenic activity of oral biofilms with or without P. denticola were examined via multiscale/computational imaging and virulence assays.

Results

P. denticola, exerting a previously unidentified mechanism in supragingival biofilms, promoted oral biofilm cariogenicity through altering the microbial ecosystem and biofilm structure. In vivo studies demonstrated that P. denticola induced the formation of a more cariogenic biofilm on supragingival tooth surfaces.

Conclusions

Collectively, P. denticola has an ecological impact on the mixed oral microbiota and disrupts microbial equilibrium. These findings indicated that P. denticola infection plays a critical role in caries occurrence.