Objective <p>The objective of this study is to evaluate the flexural strength and surface hardness of denture base resins that have been milled using computer-aided design and computer-aided manufacturing milling (CAD/CAM) and conventional heat-polymerized denture base resins (HP).</p> Methods <p>Eighty samples were made using CAD/CAM resin material (Polident CAD/CAM and Interdent CC discs) and conventional heat-polymerised acrylic resin (HP) (IvoBase CAD and PMMA). Based on the denture base material, the samples were categorised into eight groups: each group (<i>n</i> = 10), flexural strength (<i>n</i> = 40), surface hardness (<i>n</i> = 40). Both the surface hardness and flexural strength were evaluated using the Vickers hardness test and the three-point flexure test, respectively. A statistical analysis with a significance level of α = 0.05 was used to analyze the data.</p> Results <p>Compared with HP resins, milled CAD/CAM resins demonstrated significantly higher flexural strength and surface hardness (<i>p</i> &lt; 0.001). The flexural strength of MHC 72.72 ± 5.95 is significantly lower than that of IHC 78.96 ± 3.36, PCC 108.59 ± 6.51, and VCC 99.88 ± 6.05&#xa0;MPa. Surface hardness is significantly lower in MHC (18.40 ± 2.28 VHN) than in the other groups: IHC (21.30 ± 2.40 VHN), PCC (31.07 ± 2.07 VHN), and VCC (27.09 ± 1.55 VHN).</p> Conclusion <p>Compared with heat-polymerized acrylic resin, milled CAD/CAM resins performed exceptionally well in terms of flexural and surface mechanical properties.</p>