Background Gingival hyperpigmentation is a common aesthetic concern, necessitating evidence-based evaluation of depigmentation treatments, particularly vitamin C mesotherapy. Methods A systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted across PubMed, EMBASE, and Web of Science databases. Data were extracted and analyzed using both random and common effects models to calculate mean difference (MD) and 95% confidence interval (CI). Heterogeneity was assessed using I², tau², and Q statistics. Results The meta-analysis, including 11 RCTs with a total of 236 participants, revealed significant effects of vitamin C mesotherapy. For Visual Analog Scale (VAS) scores, the MD was 2.0580 [1.6161; 2.4998] (p < 0.0001), with high heterogeneity (I² = 90.6%). The overall effect for GPI scores was not statistically significant (MD = -0.72, 95% CI [-1.47, 0.03], p = 0.0585), with high heterogeneity (I2 = 95.1%). A subgroup analysis revealed a significant difference between groups (p < 0.0001). The Diode laser subgroup showed a significant effect (MD = -1.35, 95% CI [-1.64, -1.07]) with no heterogeneity, whereas the Surgical depigmentation subgroup had no significant effect and high heterogeneity (I2 = 85.9%). Dummett-Gupta Oral Pigmentation Index (DOPI) scores showed a significant decrease with mesotherapy compared to diode laser (MD = -0.7653 [-0.9207; -0.6100], p < 0.0001, I² = 0.0%), but no significant difference compared to topical gel (MD = 0.1723 [-0.1438; 0.4883], p = 0.2855, I² = 0.0%). When compared to overall laser interventions (MD = 1.7245 [1.5181; 1.9308], p < 0.0001, I² = 89.9%) and surgical interventions (MD = 2.2091 [2.0653; 2.3530], p < 0.0001, I² = 59.5%), vitamin C mesotherapy generally exhibited smaller mean differences, indicating a comparatively lesser magnitude of effect. Conclusion Vitamin C mesotherapy demonstrates significant efficacy in reducing gingival hyperpigmentation, notably showing a favorable outcome compared to diode laser for DOPI scores and no significant difference from topical gel. While laser and surgical interventions generally present larger overall mean differences, vitamin C mesotherapy remains a valuable treatment modality, adding to the diverse effective options for managing gingival hyperpigmentation.

Meta-analysis of randomized controlled trials: efficacy of vitamin C mesotherapy for gingival hyperpigmentation in adults

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2025年10月14日

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Mina Hu,
Yue Gao,
Jian Xu,
Jianying Zhao

摘要

Background

Gingival hyperpigmentation is a common aesthetic concern, necessitating evidence-based evaluation of depigmentation treatments, particularly vitamin C mesotherapy.

Methods

A systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted across PubMed, EMBASE, and Web of Science databases. Data were extracted and analyzed using both random and common effects models to calculate mean difference (MD) and 95% confidence interval (CI). Heterogeneity was assessed using I², tau², and Q statistics.

Results

The meta-analysis, including 11 RCTs with a total of 236 participants, revealed significant effects of vitamin C mesotherapy. For Visual Analog Scale (VAS) scores, the MD was 2.0580 [1.6161; 2.4998] (p < 0.0001), with high heterogeneity (I² = 90.6%). The overall effect for GPI scores was not statistically significant (MD = -0.72, 95% CI [-1.47, 0.03], p = 0.0585), with high heterogeneity (I² = 95.1%). A subgroup analysis revealed a significant difference between groups (p < 0.0001). The Diode laser subgroup showed a significant effect (MD = -1.35, 95% CI [-1.64, -1.07]) with no heterogeneity, whereas the Surgical depigmentation subgroup had no significant effect and high heterogeneity (I² = 85.9%). Dummett-Gupta Oral Pigmentation Index (DOPI) scores showed a significant decrease with mesotherapy compared to diode laser (MD = -0.7653 [-0.9207; -0.6100], p < 0.0001, I² = 0.0%), but no significant difference compared to topical gel (MD = 0.1723 [-0.1438; 0.4883], p = 0.2855, I² = 0.0%). When compared to overall laser interventions (MD = 1.7245 [1.5181; 1.9308], p < 0.0001, I² = 89.9%) and surgical interventions (MD = 2.2091 [2.0653; 2.3530], p < 0.0001, I² = 59.5%), vitamin C mesotherapy generally exhibited smaller mean differences, indicating a comparatively lesser magnitude of effect.

Conclusion

Vitamin C mesotherapy demonstrates significant efficacy in reducing gingival hyperpigmentation, notably showing a favorable outcome compared to diode laser for DOPI scores and no significant difference from topical gel. While laser and surgical interventions generally present larger overall mean differences, vitamin C mesotherapy remains a valuable treatment modality, adding to the diverse effective options for managing gingival hyperpigmentation.