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Objective <p>This study compares the effects of Nanosil<sup>®</sup> mouthwash, a multi-component formulation containing hydrogen peroxide, silver ions, eugenol, and menthol and chlorhexidine on healing, pain, and complications following impacted mandibular third molar surgery. Impacted mandibular third molars extraction, often accompanied by complications like pain, dry socket, swelling, trismus, and infection. Mouthwashes are used to reduce infection risk and promote healing by eliminating oral microorganisms.</p> Methodology <p>: This double-blind, randomized clinical trial involved 62 patients (aged 18–50 years) with Pell and Gregory A and B impacted third molars. Participants were allocated to two groups: 15&#xa0;cc of Nanosil<sup>®</sup> mouthwash and 250&#xa0;ml of 0.2% chlorhexidine mouthwash (Najo<sup>®</sup>) before and after surgery. Pain was assessed with the Visual Analog Scale (VAS), swelling was measured on days 1, 3, and 7, and wound healing was evaluated. Data were analyzed using t-tests and Mann-Whitney tests.</p> Results <p>Healing on day 3 was significantly better in the Nanosil group (<i>p</i> = 0.001). No infections or discharge were observed. A dry socket occurred in one patient in the Nanosil group, but it was not statistically significant. Swelling was significantly lower in the Nanosil group on day 3 (<i>p</i> &lt; 0.001). Pain levels were similar in both groups.</p> Conclusion <p>Nanosil promoted better healing and reduced swelling compared to chlorhexidine on the third day post-surgery. No significant differences were found regarding pain, infection, discharge, or dry socket.</p> <p><i>Trial registration:</i> The study was registered in the Iranian Clinical Trials Center with the code IRCT20171216037893N6 on 16/12/2021. <a href="https://irct.behdasht.gov.ir/trial/60568">https://irct.behdasht.gov.ir/trial/60568</a>.</p>

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Comparative effects of hydrogen peroxide (Nanosil) and chlorhexidine mouthwashes on healing and pain after impacted mandibular third molar surgery: a randomized clinical trial

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年9月24日

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  • Hamidreza Mahaseni Aghdam,
  • Saeid Kasirolvalad,
  • Esshagh Lasemi,
  • Mona Farahmand,
  • Rojin Ardalani,
  • Mohsen Shalalvand

摘要

Objective

This study compares the effects of Nanosil® mouthwash, a multi-component formulation containing hydrogen peroxide, silver ions, eugenol, and menthol and chlorhexidine on healing, pain, and complications following impacted mandibular third molar surgery. Impacted mandibular third molars extraction, often accompanied by complications like pain, dry socket, swelling, trismus, and infection. Mouthwashes are used to reduce infection risk and promote healing by eliminating oral microorganisms.

Methodology

: This double-blind, randomized clinical trial involved 62 patients (aged 18–50 years) with Pell and Gregory A and B impacted third molars. Participants were allocated to two groups: 15 cc of Nanosil® mouthwash and 250 ml of 0.2% chlorhexidine mouthwash (Najo®) before and after surgery. Pain was assessed with the Visual Analog Scale (VAS), swelling was measured on days 1, 3, and 7, and wound healing was evaluated. Data were analyzed using t-tests and Mann-Whitney tests.

Results

Healing on day 3 was significantly better in the Nanosil group (p = 0.001). No infections or discharge were observed. A dry socket occurred in one patient in the Nanosil group, but it was not statistically significant. Swelling was significantly lower in the Nanosil group on day 3 (p < 0.001). Pain levels were similar in both groups.

Conclusion

Nanosil promoted better healing and reduced swelling compared to chlorhexidine on the third day post-surgery. No significant differences were found regarding pain, infection, discharge, or dry socket.

Trial registration: The study was registered in the Iranian Clinical Trials Center with the code IRCT20171216037893N6 on 16/12/2021. https://irct.behdasht.gov.ir/trial/60568.