Objective <p>To compare the impact of the fluorinated graphene oxide nanosheets (FG) and nanohydroxyapatite (n-HAp) with and without microabrasion pretreatment on the cross sectional microhardness (CSMH) and color change (ΔE₀₀) of artificially established white spot lesions.</p> Materials and methods <p>Demineralized eighty bovine enamel samples were splited into two groups (<i>n</i> = 40) based on the remineralizing material (n-HAp or FG), subsequently divided into two subgroups (<i>n</i> = 20) dependent on microabrasion pretreatment. The samples are remineralized for thirty days. ΔE₀₀, elemental analysis employing energy-dispersive X-ray spectroscopy (EDX) along with surface features with scanning electron microscopy (SEM) was assessed. CSMH was measured at 50, 100, and 150&#xa0;μm enamel depths. Statistical analysis was performed using ANOVA and post-hoc testing (<i>p</i> &lt; 0.05).</p> Results <p>FG had the highest CSMH at 100 and 150&#xa0;μm depths while microabrasion with remineralizing has a highest CSMH at 50&#xa0;μm. EDX revealed that FG-treated specimens had the highest Ca/P ratio (<i>p</i> &lt; 0.001). FG had the highest ΔE₀₀, whereas microabrasion with n-HAp showed the least ΔE₀₀.</p> Conclusions <p>FG provides greater aesthetic enhancement and remineralization than n-HAp. microabrasion did not significantly boost the remineralization.</p> Clinical significance <p>Fluorinated graphene oxide nanosheets are a promising remineralization approach for treating white spot lesions offering improved mineral recovery and aesthetic outcomes.</p>