Scholarlink

Background <p>Vitamin D is involved in the immune system by regulating inflammatory processes. Over the recent decades, there has been an increase in studies investigating the potential influence of vitamin D status on inflammatory diseases and conditions. However, research on the link between vitamin D and periodontitis remains scarce. Hence, we aimed to examine the relationship between serum 25(OH)D levels and periodontitis in an adult population in Northern Norway.</p> Methods <p>The study was based on cross-sectional data from a population-based study: the seventh Tromsø study, conducted in 2015 – 2016. Eligible participants were adults ( ≥ 40&#xa0;years old) who had both a valid periodontal diagnosis and data on serum 25(OH)D levels, giving a total study sample of <i>n</i> = 3,693 participants (51.4% women). Periodontitis was defined according to the 2017 AAP/EFP classification system. Two groups were compared: no-periodontitis/stage I periodontitis versus stages II-III/IV periodontitis. Using a bivariate logistic regression analysis, the association between these two groups and serum 25(OH)D was tested, controlling for age, sex, smoking, toothbrushing frequency, and socioeconomic status. Periodontal pockets of ≥ 5&#xa0;mm and their association with serum 25(OH)D were also tested.</p> Results <p>About 89% were classified as having periodontitis, and 51.6% had stages II–III/IV periodontitis. About 4% of the participants were at deficient levels of serum 25(OH)D (&lt; 30&#xa0;nmol/L). Levels of serum 25(OH)D of &lt; 30&#xa0;nmol/L were associated with periodontitis stage II-III/IV (odds ratio [OR] 1.53, 95% confidence interval [CI]: 1.03–2.28). Stratified by when the season serum 25(OH)D was measured (March-September vs October-February), the summer strata was significantly associated with periodontitis II-III/IV (30–50&#xa0;nmol/L = OR 1.31, 95% CI:1.05–1.63, <i>p</i> = 0.018). Vitamin D deficiency and insufficiency were associated with having at least one periodontal pocket of ≥ 5&#xa0;mm (&lt; 30&#xa0;nmol/L = 1.78, 95% CI:1.22–2.60, <i>p</i> = 0.003: 30–50&#xa0;nmol/L = OR was 1.23, 95% CI:1.03–1.47, <i>p</i> = 0.020, respectively).</p> Conclusion <p>In this Norwegian adult population, blood 25-hydroxy vitamin D [25(OH)D] levels were associated to periodontitis stage II-III/IV and a periodontal pocket depth of ≥ 5&#xa0;mm.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Cross-sectional associations between vitamin D status and periodontitis in adults in Northern Norway: The Tromsø Study 2015–2016

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年5月30日

查看全文
  • Fanny Maria Lindholm,
  • Birgitta Jönsson,
  • Magritt Brustad

摘要

Background

Vitamin D is involved in the immune system by regulating inflammatory processes. Over the recent decades, there has been an increase in studies investigating the potential influence of vitamin D status on inflammatory diseases and conditions. However, research on the link between vitamin D and periodontitis remains scarce. Hence, we aimed to examine the relationship between serum 25(OH)D levels and periodontitis in an adult population in Northern Norway.

Methods

The study was based on cross-sectional data from a population-based study: the seventh Tromsø study, conducted in 2015 – 2016. Eligible participants were adults ( ≥ 40 years old) who had both a valid periodontal diagnosis and data on serum 25(OH)D levels, giving a total study sample of n = 3,693 participants (51.4% women). Periodontitis was defined according to the 2017 AAP/EFP classification system. Two groups were compared: no-periodontitis/stage I periodontitis versus stages II-III/IV periodontitis. Using a bivariate logistic regression analysis, the association between these two groups and serum 25(OH)D was tested, controlling for age, sex, smoking, toothbrushing frequency, and socioeconomic status. Periodontal pockets of ≥ 5 mm and their association with serum 25(OH)D were also tested.

Results

About 89% were classified as having periodontitis, and 51.6% had stages II–III/IV periodontitis. About 4% of the participants were at deficient levels of serum 25(OH)D (< 30 nmol/L). Levels of serum 25(OH)D of < 30 nmol/L were associated with periodontitis stage II-III/IV (odds ratio [OR] 1.53, 95% confidence interval [CI]: 1.03–2.28). Stratified by when the season serum 25(OH)D was measured (March-September vs October-February), the summer strata was significantly associated with periodontitis II-III/IV (30–50 nmol/L = OR 1.31, 95% CI:1.05–1.63, p = 0.018). Vitamin D deficiency and insufficiency were associated with having at least one periodontal pocket of ≥ 5 mm (< 30 nmol/L = 1.78, 95% CI:1.22–2.60, p = 0.003: 30–50 nmol/L = OR was 1.23, 95% CI:1.03–1.47, p = 0.020, respectively).

Conclusion

In this Norwegian adult population, blood 25-hydroxy vitamin D [25(OH)D] levels were associated to periodontitis stage II-III/IV and a periodontal pocket depth of ≥ 5 mm.