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Background <p>The possible anti-Mullerian hormone (AMH)-reduction impact of metabolic bariatric surgery has been assessed in a number of interventional investigations. The outcomes are still incongruous, however. This research sought to thoroughly examine the effects of metabolic bariatric surgery on AMH in order to have a better understanding of them.</p> Methods <p>Using standard keywords, the Scopus, PubMed/Medline, Web of Science, Cochrane, and Embase databases were searched to find all eligible human studies, including observational cohorts and single-arm pre–post studies, examining the levels of AMH after metabolic bariatric surgery treatment. For the best result estimate, random-effects model analysis produced 95% confidence intervals and a pooled weighted mean difference.</p> Results <p>This article includes 15 treatment arms with a total of 459 participants. The results from the random-effects meta-analysis showed a significant reduction in AMH levels in the included observational and pre–post studies, with a pooled weighted mean difference (WMD) of −0.58 ng/ml [95% confidence interval (CI): −1.10 to −0.06; <i>p</i> = 0.028]. Subgroup analysis indicated that metabolic bariatric surgery had a greater effect on AMH reduction in the population with PCOS, with a time after the intervention of 48 weeks or longer, and in participants aged 30 years or younger compared to other groups.</p> Conclusions <p>This meta-analysis suggests that metabolic bariatric surgery is associated with reductions in AMH, particularly in women with PCOS. However, due to high heterogeneity, low-quality evidence, and lack of fertility outcomes, these results should be interpreted with caution. The implications for fertility remain uncertain.</p>

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The effect of metabolic bariatric surgery on Anti-Müllerian hormone levels: a systematic review and meta-regression analysis

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年3月16日

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  • Mehdi Mehdinezhad Roshan,
  • Neda Davaryari,
  • Fateme Cheshmi,
  • Parnia Pouya,
  • Seyyed Amir Moradian,
  • Mohammad Hassan Sohouli,
  • Hamed Hajpour,
  • Maryam Salehi Novin,
  • Behnaz Sadeghzadeh Oskouei,
  • Elma Izze da Silva Magalhães

摘要

Background

The possible anti-Mullerian hormone (AMH)-reduction impact of metabolic bariatric surgery has been assessed in a number of interventional investigations. The outcomes are still incongruous, however. This research sought to thoroughly examine the effects of metabolic bariatric surgery on AMH in order to have a better understanding of them.

Methods

Using standard keywords, the Scopus, PubMed/Medline, Web of Science, Cochrane, and Embase databases were searched to find all eligible human studies, including observational cohorts and single-arm pre–post studies, examining the levels of AMH after metabolic bariatric surgery treatment. For the best result estimate, random-effects model analysis produced 95% confidence intervals and a pooled weighted mean difference.

Results

This article includes 15 treatment arms with a total of 459 participants. The results from the random-effects meta-analysis showed a significant reduction in AMH levels in the included observational and pre–post studies, with a pooled weighted mean difference (WMD) of −0.58 ng/ml [95% confidence interval (CI): −1.10 to −0.06; p = 0.028]. Subgroup analysis indicated that metabolic bariatric surgery had a greater effect on AMH reduction in the population with PCOS, with a time after the intervention of 48 weeks or longer, and in participants aged 30 years or younger compared to other groups.

Conclusions

This meta-analysis suggests that metabolic bariatric surgery is associated with reductions in AMH, particularly in women with PCOS. However, due to high heterogeneity, low-quality evidence, and lack of fertility outcomes, these results should be interpreted with caution. The implications for fertility remain uncertain.