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Background <p>Antibiotic resistance and the emergence of antimicrobial resistance (AMR) threaten global health. It is necessary to explore new solutions, such as the use of metal-based nanoparticles and nanomaterials for antimicrobial photodynamic/photothermal therapy (aPDT/aPTT). In this paper, we investigated the antibacterial effect, PTT, and PDT performance of biogenic silver nanoparticles (AgNPs) and nanostructures derived from them.</p> Method <p>Biogenic AgNPs (<i>R. crispus</i> seeds mediated AgNPs, RC-AgNPs) are produced by the extract of the <i>R. crispus</i> seeds. The morphology of RC-AgNPs-treated bacteria was studied using scanning electron microscopy (SEM). Then RC-AgNP @ poly-G was synthesized by the interaction of poly-G with biogenic AgNPs. Nanostructures characterized by UV-visible spectroscopy, Fourier-transform infrared (FT-IR), dynamic light scattering (DLS), X-ray diffraction (XRD), and transmission electron microscopy (TEM). The entropy and temperature studies of poly G secondary structure were carried out using the Vienna RNA secondary structure server and UV-visible spectroscopy at 25°, 37°, and 40° C.</p> Results <p>Results have shown that RC-AgNPs and RC-AgNP @ poly-G exhibit a synergistic antibacterial effect with PTT and PDT.</p> Conclusions <p>In summary, these nanoparticles could be nanotheranostic agents. They have acceptable potential in the therapy and diagnosis of infectious and non-infectious diseases. Consequently, they are good objectives for future research.</p>

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Green synthesis of silver nanoparticles using Rumex. crispus seeds and synergistic application of photodynamic/photothermal antimicrobial therapy

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年2月25日

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  • Atiyeh Nomani,
  • MohammadReza Aghdaee,
  • Sajad Shariat,
  • Naser Faraji,
  • Siamak Javani

摘要

Background

Antibiotic resistance and the emergence of antimicrobial resistance (AMR) threaten global health. It is necessary to explore new solutions, such as the use of metal-based nanoparticles and nanomaterials for antimicrobial photodynamic/photothermal therapy (aPDT/aPTT). In this paper, we investigated the antibacterial effect, PTT, and PDT performance of biogenic silver nanoparticles (AgNPs) and nanostructures derived from them.

Method

Biogenic AgNPs (R. crispus seeds mediated AgNPs, RC-AgNPs) are produced by the extract of the R. crispus seeds. The morphology of RC-AgNPs-treated bacteria was studied using scanning electron microscopy (SEM). Then RC-AgNP @ poly-G was synthesized by the interaction of poly-G with biogenic AgNPs. Nanostructures characterized by UV-visible spectroscopy, Fourier-transform infrared (FT-IR), dynamic light scattering (DLS), X-ray diffraction (XRD), and transmission electron microscopy (TEM). The entropy and temperature studies of poly G secondary structure were carried out using the Vienna RNA secondary structure server and UV-visible spectroscopy at 25°, 37°, and 40° C.

Results

Results have shown that RC-AgNPs and RC-AgNP @ poly-G exhibit a synergistic antibacterial effect with PTT and PDT.

Conclusions

In summary, these nanoparticles could be nanotheranostic agents. They have acceptable potential in the therapy and diagnosis of infectious and non-infectious diseases. Consequently, they are good objectives for future research.