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Objective <p>Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS) is an important public health problem that mainly affects middle-aged female patients. Diagnosis of IC/BPS is difficult as there is no disease-specific diagnostic test. Our study evaluated routine hematological parameters in female IC/BPS patients to determine their potential utility in supporting diagnosis and reflecting disease severity.</p> Methods <p>Fifty female IC/BPS patients and 50 age-matched healthy controls were compared regarding neutrophil, lymphocyte, platelet counts, mean platelet volume (MPV), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR). In the patient group, correlations between these parameters and O’Leary-Sant Interstitial Cystitis Symptom Index (ICSI) scores were analyzed.</p> Results <p>Neutrophil, lymphocyte, platelet counts, and MPV values were similar between groups, whereas NLR was significantly higher in IC/BPS patients (2.34 vs. 1.85, <i>p</i> &lt; 0.001). Among patients, lymphocyte counts were higher in those with ICSI ≥ 14 compared with ICSI &lt; 14 (1.90 vs. 1.62, <i>p</i> = 0.009).</p> Conclusion <p>Elevated NLR may serve as an adjunctive marker supporting the diagnostic evaluation of IC/BPS, while lymphocyte count may be related to symptom severity. These routinely available parameters could offer additional clinical insight; however, their role should be confirmed in larger, prospective studies.</p>

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Investigation of the hematological parameters in women with Interstitial Cystitis/Bladder Pain Syndrome and their relationship with disease severity

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年2月19日

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  • Mehmet Altan,
  • Ahmet Emin Dogan,
  • Fatih Sandikci,
  • Sertac Cimen

摘要

Objective

Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS) is an important public health problem that mainly affects middle-aged female patients. Diagnosis of IC/BPS is difficult as there is no disease-specific diagnostic test. Our study evaluated routine hematological parameters in female IC/BPS patients to determine their potential utility in supporting diagnosis and reflecting disease severity.

Methods

Fifty female IC/BPS patients and 50 age-matched healthy controls were compared regarding neutrophil, lymphocyte, platelet counts, mean platelet volume (MPV), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR). In the patient group, correlations between these parameters and O’Leary-Sant Interstitial Cystitis Symptom Index (ICSI) scores were analyzed.

Results

Neutrophil, lymphocyte, platelet counts, and MPV values were similar between groups, whereas NLR was significantly higher in IC/BPS patients (2.34 vs. 1.85, p < 0.001). Among patients, lymphocyte counts were higher in those with ICSI ≥ 14 compared with ICSI < 14 (1.90 vs. 1.62, p = 0.009).

Conclusion

Elevated NLR may serve as an adjunctive marker supporting the diagnostic evaluation of IC/BPS, while lymphocyte count may be related to symptom severity. These routinely available parameters could offer additional clinical insight; however, their role should be confirmed in larger, prospective studies.