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Background <p>Keloids are rare but challenging complications in penile surgeries, including circumcision. The President’s Emergency Plan for AIDS Relief (PEPFAR) supports voluntary medical male circumcisions (VMMC) for HIV prevention in sub-Saharan Africa, and has monitored major adverse events through its Notifiable Adverse Event Reporting system (NAER) since 2015, providing unique opportunities to understand keloid epidemiology and risk factors.</p> Methods <p>All 2015–2023 NAER keloid cases were reviewed. Variables abstracted included age at VMMC, time course, and case characteristics. Descriptive analysis and Fisher’s exact test of the association between client age (&lt; 15&#xa0;years vs. ≥ 15&#xa0;years) and keloids were performed. Systematic literature searches were also conducted on case reports, outcomes and management guidelines, to produce a narrative summary and comparisons between the NAER cases and prior literature.</p> Results <p>Eleven cases were reported. Clients were &lt; 15&#xa0;years old in 10/11, with median age 12&#xa0;years and mean time to diagnosis 1.8&#xa0;years. Clients aged 10–14&#xa0;years had a significantly higher risk for keloids compared to those aged 15 and older (<i>p</i> = 0.0004). Case characteristics were similar to those in prior case series, as was management, except that silicone gels or sheeting were not used. Follow-up was too brief to assess outcomes.</p> Conclusions <p>Keloids were a rare complication of PEPFAR-supported VMMCs. Keloids were strongly associated with age 10–14&#xa0;years at circumcision as compared to older age. Programs can remind clients to return to VMMC sites even for late complications, and develop expert referral networks. Silicone gels or sheeting could represent an additional conservative management option.</p>

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Keloids as a rare complication of voluntary medical male circumcision: findings from PEPFAR’s notifiable adverse events reporting system

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年1月16日

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  • Stephanie Davis,
  • Eniko Akom,
  • Valerian Kiggundu,
  • Sarah Nabukera,
  • Anne Thomas,
  • Daimon Simbeye,
  • Oscar Ernest Rwabiyago,
  • Suzan Mmbando,
  • Alick Kayange,
  • Neway Fida,
  • John Mandisarisa,
  • Tungamirai Mhuka,
  • Wezi Msungama,
  • Martin Kapito,
  • Faustin Matchere,
  • Martin Maulidi,
  • Elijah Odoyo-June,
  • Leonard Soo,
  • Ambrose Juma,
  • Todd Lucas

摘要

Background

Keloids are rare but challenging complications in penile surgeries, including circumcision. The President’s Emergency Plan for AIDS Relief (PEPFAR) supports voluntary medical male circumcisions (VMMC) for HIV prevention in sub-Saharan Africa, and has monitored major adverse events through its Notifiable Adverse Event Reporting system (NAER) since 2015, providing unique opportunities to understand keloid epidemiology and risk factors.

Methods

All 2015–2023 NAER keloid cases were reviewed. Variables abstracted included age at VMMC, time course, and case characteristics. Descriptive analysis and Fisher’s exact test of the association between client age (< 15 years vs. ≥ 15 years) and keloids were performed. Systematic literature searches were also conducted on case reports, outcomes and management guidelines, to produce a narrative summary and comparisons between the NAER cases and prior literature.

Results

Eleven cases were reported. Clients were < 15 years old in 10/11, with median age 12 years and mean time to diagnosis 1.8 years. Clients aged 10–14 years had a significantly higher risk for keloids compared to those aged 15 and older (p = 0.0004). Case characteristics were similar to those in prior case series, as was management, except that silicone gels or sheeting were not used. Follow-up was too brief to assess outcomes.

Conclusions

Keloids were a rare complication of PEPFAR-supported VMMCs. Keloids were strongly associated with age 10–14 years at circumcision as compared to older age. Programs can remind clients to return to VMMC sites even for late complications, and develop expert referral networks. Silicone gels or sheeting could represent an additional conservative management option.