Scholarlink

Objectives <p>To determine risk factors associated with the recurrence of renal cell carcinoma (RCC), either local recurrence or distant metastasis, and to characterize a contemporary cohort of patients with non-clear RCC (ncRCC) in terms of cancer-free survival (CFS) and time to such recurrence.</p> Methods <p>A retrospective review of prospectively collected data was performed for consecutive patients undergoing partial and radical nephrectomy at a tertiary care center in Saudi Arabia. Data collection included patients and tumor characteristics, perioperative parameters, and histopathological patterns. Multivariate logistic regression determined the predictors of tumor recurrence while Kaplan-Meier analyses assessed CFS and the time to recurrence.</p> Results <p>A total of 214 patients were analyzed, including 150 (70.1%) ccRCC and 64 (29.9%) ncRCC, with a mean age of 54.8 ± 1.7 years and tumor size of 6.9 ± 0.7 (1.2–24.0) cm. After a median follow-up of 47.6 ± 12.4 months, 32(14.9%) patients developed recurrence. In multivariate regression, tumor recurrence was significantly associated with tumors ≥ 6.9&#xa0;cm [aOR (95% CI): 2.85 (1.67–5.43)], renal vein or inferior vena cava vascular invasion [aOR: 1.92 (1.32–4.21)], pathological staging ≥ 2b [aOR: 2.66 (1.95–5.34)] (8th edition of the AJCC Cancer Staging Manual, 2017), and positive lymph nodes in the specimen [aOR: 3.28 (2.97–5.15)]. The recurrence-free status was 85% at 5 years, while the mean time to recurrence was 9 (6–42) months. Patients with ncRCC had comparable recurrence rates to those with ccRCC (12.5% vs. 16.0% <i>p</i> = 0.64), respectively. The 5-year CFS was 62.8% (95% CI: 54.2–68.7) for ncRCC and 76.8% (95% CI: 67.4–87.2) for ccRCC (<i>p</i> = 0.77).</p> Conclusion <p>Compared to clear cell RCC, patients with non-clear cell RCC showed no significant differences in demographic, tumor, or perioperative characteristics. In our cohort, both histopathological subtypes demonstrated comparable recurrence rates and 5-year cancer-free survival.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Prognostic impact of non-clear cell histology on recurrence and cancer-free survival in renal cell carcinoma: a time-to-event analysis

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年9月26日

查看全文
  • Waseem Tayeb,
  • Abdulaziz Bakhsh,
  • Mahmoud Faisal,
  • Mohnna Subahi,
  • Hashim Naji,
  • Hattan Badr,
  • Turky Almohaisen,
  • Sameer Munshi,
  • Mohamed A. Elkoushy

摘要

Objectives

To determine risk factors associated with the recurrence of renal cell carcinoma (RCC), either local recurrence or distant metastasis, and to characterize a contemporary cohort of patients with non-clear RCC (ncRCC) in terms of cancer-free survival (CFS) and time to such recurrence.

Methods

A retrospective review of prospectively collected data was performed for consecutive patients undergoing partial and radical nephrectomy at a tertiary care center in Saudi Arabia. Data collection included patients and tumor characteristics, perioperative parameters, and histopathological patterns. Multivariate logistic regression determined the predictors of tumor recurrence while Kaplan-Meier analyses assessed CFS and the time to recurrence.

Results

A total of 214 patients were analyzed, including 150 (70.1%) ccRCC and 64 (29.9%) ncRCC, with a mean age of 54.8 ± 1.7 years and tumor size of 6.9 ± 0.7 (1.2–24.0) cm. After a median follow-up of 47.6 ± 12.4 months, 32(14.9%) patients developed recurrence. In multivariate regression, tumor recurrence was significantly associated with tumors ≥ 6.9 cm [aOR (95% CI): 2.85 (1.67–5.43)], renal vein or inferior vena cava vascular invasion [aOR: 1.92 (1.32–4.21)], pathological staging ≥ 2b [aOR: 2.66 (1.95–5.34)] (8th edition of the AJCC Cancer Staging Manual, 2017), and positive lymph nodes in the specimen [aOR: 3.28 (2.97–5.15)]. The recurrence-free status was 85% at 5 years, while the mean time to recurrence was 9 (6–42) months. Patients with ncRCC had comparable recurrence rates to those with ccRCC (12.5% vs. 16.0% p = 0.64), respectively. The 5-year CFS was 62.8% (95% CI: 54.2–68.7) for ncRCC and 76.8% (95% CI: 67.4–87.2) for ccRCC (p = 0.77).

Conclusion

Compared to clear cell RCC, patients with non-clear cell RCC showed no significant differences in demographic, tumor, or perioperative characteristics. In our cohort, both histopathological subtypes demonstrated comparable recurrence rates and 5-year cancer-free survival.