Background <p>Infantile hypertrophic pyloric stenosis is characterized by enlarged pyloric musculature and gastric outlet obstruction. In developing countries, it results in a high rate of malnutrition, dehydration, electrolyte and acid-base imbalance and associated mortality. Ramstedt’s pyloromyotomy is the commonest procedure used to treat Infantile hypertrophic pyloric stenosis in Ethiopia, particularly in the study area. However, treatment outcomes of the procedure were not well addressed in Ethiopia, particularly at the study area.</p> Objective <p>To assess outcomes of open Ramstedt’s pyloromyotomy among Infantile hypertrophic pyloric stenosis patients who underwent open Ramstedt’s pyloromyotomy at government hospitals in Amhara Region, Ethiopia, 2023.</p> Methods <p>A facility based cross-sectional study was conducted among 119 Infantile hypertrophic pyloric stenosis patients operated with open Ramstedt’s pyloromyotomy at government hospitals. Hospitals were selected by simple random sampling. The data were collected using a data extraction checklist prepared in English language. The data were analyzed using Statistical Package for Social Science (SPSS) version 27. Descriptive statistics was used to describe the characteristics of the study participants.</p> Results <p>In this study the clinical records of 119 infants were retrieved from three government hospitals. Majority (78.2%) of the study participants were male. All infants had nonbilious vomiting and more than one thirds (34.5%) had malnutrition during admission. The overall proportion of poor outcome was 35.3% (mortality = 0.8% and morbidities = 34.5%). Prolonged preoperative hospital stay, hypokalemia and hypochloremia were the common poor outcome.</p> Conclusion <p>The mortality rate is significantly decreased, but there were still significant morbidities in this group of patients. High proportion of malnutrition, hypokalemia, and hypochloremia found at the time of admission underscores a critical pattern of delayed healthcare-seeking.</p>