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<p>The present study aimed to investigate the efficacy of indocyanine green (ICG) fluorescence-guided laparoscopic hepatectomy for the treatment of liver metastases. Therefore, data from patients with liver metastases who underwent laparoscopic hepatectomy were retrospectively collected. A total of 69 patients were divided into the ICG group (fluorescence-guided) and conventional group, with 24 well-matched pairs analyzed after propensity score matching. Laparoscopic hepatectomy was successfully performed in all patients.The ICG group had significantly wider surgical margins than the conventional group (1.73 ± 0.57&#xa0;cm vs. 1.04 ± 0.44&#xa0;cm; <i>P</i> &lt; 0.001). Pre-matching R0 resection rates were 91.9% (ICG) and 90.6% (conventional), with 100% R0 resection achieved in both groups post-matching. Operative time, intraoperative blood loss and postoperative ALT levels were numerically lower in the ICG group without statistical significance. The rates of overall/severe (Clavien–Dindo ≥IIIa) complications and 6-month recurrence were comparable between the two groups (all <i>P</i> &gt; 0.05). In conclusion, ICG fluorescence-guided laparoscopic hepatectomy is safe and feasible for liver metastases, yielding significantly wider surgical margins. Although perioperative outcomes and 6-month recurrence rates were comparable between groups after matching, the ICG-guided approach achieved significantly wider surgical margins—a finding with potential implications for long-term oncological outcomes that warrant further investigation.</p>

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Application of indocyanine green fluorescence-guided laparoscopic hepatectomy in patients with liver metastases: a retrospective single‑center study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年5月25日

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  • Lei Liu,
  • Minjing Shen,
  • Qi Wang,
  • Pingchuan Ma,
  • Yin Yin,
  • Fubao Liu,
  • Chunxia Ren,
  • Qingxiang Xu

摘要

The present study aimed to investigate the efficacy of indocyanine green (ICG) fluorescence-guided laparoscopic hepatectomy for the treatment of liver metastases. Therefore, data from patients with liver metastases who underwent laparoscopic hepatectomy were retrospectively collected. A total of 69 patients were divided into the ICG group (fluorescence-guided) and conventional group, with 24 well-matched pairs analyzed after propensity score matching. Laparoscopic hepatectomy was successfully performed in all patients.The ICG group had significantly wider surgical margins than the conventional group (1.73 ± 0.57 cm vs. 1.04 ± 0.44 cm; P < 0.001). Pre-matching R0 resection rates were 91.9% (ICG) and 90.6% (conventional), with 100% R0 resection achieved in both groups post-matching. Operative time, intraoperative blood loss and postoperative ALT levels were numerically lower in the ICG group without statistical significance. The rates of overall/severe (Clavien–Dindo ≥IIIa) complications and 6-month recurrence were comparable between the two groups (all P > 0.05). In conclusion, ICG fluorescence-guided laparoscopic hepatectomy is safe and feasible for liver metastases, yielding significantly wider surgical margins. Although perioperative outcomes and 6-month recurrence rates were comparable between groups after matching, the ICG-guided approach achieved significantly wider surgical margins—a finding with potential implications for long-term oncological outcomes that warrant further investigation.