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<p>The recently published pediatric appendicitis score demonstrates promising discriminative performance. However, key methodological aspects—including predictor handling, possible predictor redundancy or multicollinearity, absence of calibration analysis, internal validation, and post hoc cut-off selection—limit interpretability and clinical transportability. In this comment, these methodological aspects are critically and constructively examined to facilitate clearer interpretation and enhance methodological transparency.</p>

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Letter to the editor regarding the article “Development of a new predictive clinico-biological score for acute appendicitis in the pediatric population”

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年6月1日

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  • Javier Arredondo Montero

摘要

The recently published pediatric appendicitis score demonstrates promising discriminative performance. However, key methodological aspects—including predictor handling, possible predictor redundancy or multicollinearity, absence of calibration analysis, internal validation, and post hoc cut-off selection—limit interpretability and clinical transportability. In this comment, these methodological aspects are critically and constructively examined to facilitate clearer interpretation and enhance methodological transparency.