Scholarlink

Background <p>Giant retroperitoneal tumors are rare and pose significant surgical challenges due to delayed presentation, massive size, and complex anatomical relationships. Although these tumors encompass biologically heterogeneous entities, many share common surgical features that complicate operative management, particularly in cases with predominant spindle cell histology.</p> Methods <p>We retrospectively reviewed five cases of giant retroperitoneal tumors with spindle cell histology managed surgically at our institution. Data collected included clinical presentation, preoperative imaging, operative strategy, extent of resection, histopathological and immunohistochemical findings, and short-term postoperative outcomes.</p> Results <p>The cohort included five patients with retroperitoneal tumors ranging from 10 to 40&#xa0;cm in maximum dimension. Histopathological diagnoses comprised gastrointestinal stromal tumor, desmoid-type fibromatosis, and liposarcoma subtypes. All patients underwent open surgical resection, with multivisceral dissection performed when required to achieve complete macroscopic tumor removal. No major perioperative complications occurred. All patients experienced significant symptomatic improvement following surgery. During a median follow-up of six months, no early local recurrence was detected.</p> Conclusion <p>Surgical resection of giant retroperitoneal tumors is feasible and can be performed safely with acceptable short-term outcomes when guided by careful preoperative planning and individualized operative strategy. Given the heterogeneity of tumor subtypes and limited follow-up, this case series should be interpreted as a demonstration of surgical feasibility and perioperative safety rather than oncologic efficacy. Tumor size and anatomical complexity remain the primary determinants of surgical approach in extreme retroperitoneal disease.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Surgical management and immunohistochemical diagnosis of giant retroperitoneal tumors with spindle cell histology: a five-case case series

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年6月18日

查看全文
  • Mahmoud Azhary,
  • Mohamed Hassan Ali,
  • Ahmed Othman Elansary,
  • Ahmed Maher Abd Elmonim,
  • Miran Atif Elkordy,
  • Ahmed Shafik Jr.,
  • Mohamed Elshal

摘要

Background

Giant retroperitoneal tumors are rare and pose significant surgical challenges due to delayed presentation, massive size, and complex anatomical relationships. Although these tumors encompass biologically heterogeneous entities, many share common surgical features that complicate operative management, particularly in cases with predominant spindle cell histology.

Methods

We retrospectively reviewed five cases of giant retroperitoneal tumors with spindle cell histology managed surgically at our institution. Data collected included clinical presentation, preoperative imaging, operative strategy, extent of resection, histopathological and immunohistochemical findings, and short-term postoperative outcomes.

Results

The cohort included five patients with retroperitoneal tumors ranging from 10 to 40 cm in maximum dimension. Histopathological diagnoses comprised gastrointestinal stromal tumor, desmoid-type fibromatosis, and liposarcoma subtypes. All patients underwent open surgical resection, with multivisceral dissection performed when required to achieve complete macroscopic tumor removal. No major perioperative complications occurred. All patients experienced significant symptomatic improvement following surgery. During a median follow-up of six months, no early local recurrence was detected.

Conclusion

Surgical resection of giant retroperitoneal tumors is feasible and can be performed safely with acceptable short-term outcomes when guided by careful preoperative planning and individualized operative strategy. Given the heterogeneity of tumor subtypes and limited follow-up, this case series should be interpreted as a demonstration of surgical feasibility and perioperative safety rather than oncologic efficacy. Tumor size and anatomical complexity remain the primary determinants of surgical approach in extreme retroperitoneal disease.