Scholarlink

Objective <p>Minimally invasive surgery, particularly laparoscopic cholecystectomy, has become the standard treatment for gallbladder disease. However, postoperative recurrence of common bile duct stones (CBDS) remains a clinically significant complication that compromises recovery and long-term outcomes. This study aimed to identify independent risk factors associated with CBDS following laparoscopic cholecystectomy and to develop a visual predictive model for early warning and individualized postoperative management.</p> Methods <p>We collected data from 891patients who underwent cholecystectomy at Affiliated Hospital Group of Guangdong Medical University Panyu He Xian Memorial Hospital (Panyu District, Guangzhou) between September 2021and September 2024, Patients were followed for 12 months postoperatively, and 80 developed recurrent CBD stones. Demographic characteristics (age, history of liver fluke infection) and perioperative laboratory indicators (C-reactive protein [CRP], alanine aminotransferase [ALT], total bilirubin [TB], and common bile duct diameter) were compared using SPSS 27.0. Univariate and multivariate logistic regression analyses, combined with LASSO regression, were employed to identify independent predictors, which were incorporated into a nomogram model. Model performance was assessed by discrimination (AUC), calibration (calibration curve and Hosmer–Lem show test), and clinical utility (decision curve analysis), with internal validation via bootstrapping (1,000 repetitions).</p> Results <p>Multivariate analysis identified six independent predictors of CBD stone recurrence: older age (OR = 1.03 per year, 95% CI: 1.01–1.07, <i>P</i> = 0.019), elevated CRP (OR = 1.03 per mg/L, 95% CI: 1.00–1.07, <i>P</i> = 0.023), higher ALT (OR = 1.02 per U/L, 95% CI: 1.01–1.02, <i>P</i> &lt; 0.001), increased TB (OR = 1.02 per µmol/L, 95% CI: 0.99–1.05, <i>P</i> = 0.14, considered clinically relevant despite marginal statistical significance), larger CBD diameter (OR = 1.60 per mm, 95% CI: 1.27–2.01, <i>P</i> &lt; 0.001), and positive liver fluke infection history (OR = 2.09, 95% CI: 0.85–5.16, <i>P</i> = 0.108, retained due to strong epidemiological and biological plausibility). The final nomogram demonstrated excellent discrimination with an AUC of 0.835 (95% CI: 0.773–0.896) and good calibration (mean absolute error = 0.033). Internal validation confirmed robustness (bootstrap-corrected C-index = 0.835). Decision curve analysis indicated that the model provided superior net clinical benefit compared to treat-all or treat-none strategies across a wide range of risk thresholds (10%–30%).</p> Conclusion <p>Our predictive model integrates key perioperative factors—including age, CRP, ALT, TB, common bile duct diameter and liver fluke infection—to accurately identify patients at high risk of CBDS recurrence after laparoscopic cholecystectomy. This nomogram enables personalized postoperative surveillance and early intervention in minimally invasive biliary surgery, ultimately supporting enhanced recovery and precision surgical care.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Predictive modeling and risk factor analysis of common bile duct stones after laparoscopic cholecystectomy: implications for postoperative management in minimally invasive surgery

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年3月27日

查看全文
  • Wenjie Zhang,
  • Shanshan Wu,
  • Duhui Gong,
  • Yonghui Peng

摘要

Objective

Minimally invasive surgery, particularly laparoscopic cholecystectomy, has become the standard treatment for gallbladder disease. However, postoperative recurrence of common bile duct stones (CBDS) remains a clinically significant complication that compromises recovery and long-term outcomes. This study aimed to identify independent risk factors associated with CBDS following laparoscopic cholecystectomy and to develop a visual predictive model for early warning and individualized postoperative management.

Methods

We collected data from 891patients who underwent cholecystectomy at Affiliated Hospital Group of Guangdong Medical University Panyu He Xian Memorial Hospital (Panyu District, Guangzhou) between September 2021and September 2024, Patients were followed for 12 months postoperatively, and 80 developed recurrent CBD stones. Demographic characteristics (age, history of liver fluke infection) and perioperative laboratory indicators (C-reactive protein [CRP], alanine aminotransferase [ALT], total bilirubin [TB], and common bile duct diameter) were compared using SPSS 27.0. Univariate and multivariate logistic regression analyses, combined with LASSO regression, were employed to identify independent predictors, which were incorporated into a nomogram model. Model performance was assessed by discrimination (AUC), calibration (calibration curve and Hosmer–Lem show test), and clinical utility (decision curve analysis), with internal validation via bootstrapping (1,000 repetitions).

Results

Multivariate analysis identified six independent predictors of CBD stone recurrence: older age (OR = 1.03 per year, 95% CI: 1.01–1.07, P = 0.019), elevated CRP (OR = 1.03 per mg/L, 95% CI: 1.00–1.07, P = 0.023), higher ALT (OR = 1.02 per U/L, 95% CI: 1.01–1.02, P < 0.001), increased TB (OR = 1.02 per µmol/L, 95% CI: 0.99–1.05, P = 0.14, considered clinically relevant despite marginal statistical significance), larger CBD diameter (OR = 1.60 per mm, 95% CI: 1.27–2.01, P < 0.001), and positive liver fluke infection history (OR = 2.09, 95% CI: 0.85–5.16, P = 0.108, retained due to strong epidemiological and biological plausibility). The final nomogram demonstrated excellent discrimination with an AUC of 0.835 (95% CI: 0.773–0.896) and good calibration (mean absolute error = 0.033). Internal validation confirmed robustness (bootstrap-corrected C-index = 0.835). Decision curve analysis indicated that the model provided superior net clinical benefit compared to treat-all or treat-none strategies across a wide range of risk thresholds (10%–30%).

Conclusion

Our predictive model integrates key perioperative factors—including age, CRP, ALT, TB, common bile duct diameter and liver fluke infection—to accurately identify patients at high risk of CBDS recurrence after laparoscopic cholecystectomy. This nomogram enables personalized postoperative surveillance and early intervention in minimally invasive biliary surgery, ultimately supporting enhanced recovery and precision surgical care.