Scholarlink

Background <p>Surgical site infections (SSI) and wound complications are major concerns in colorectal cancer (CRC) surgery. Negative pressure wound therapy (NPWT) has been proposed to reduce these complications, but its efficacy specifically in CRC surgery remains uncertain. This meta-analysis evaluates the impact of NPWT on surgical wound outcomes compared to standard wound care in patients undergoing CRC surgery.</p> Methods <p>A systematic search of PubMed, Scopus, Web of Science, and Cochrane Library was conducted up to February 10, 2025, for studies comparing NPWT with standard wound care in CRC surgery patients. The primary outcome was total wound complications. Risk ratios (RR) and mean differences (MD) were pooled using a random-effects model, with heterogeneity assessed using I² statistics.</p> Results <p>Six studies involving 343 patients (NPWT: 171, control: 172) were included. NPWT did not significantly reduce total wound complications (RR: 0.67, 95% CI: 0.35–1.26, <i>P</i> = 0.21, I² = 66%). Similarly, no significant differences were found for SSI (RR: 0.80, 95% CI: 0.45–1.43, <i>P</i> = 0.45), even after sensitivity analysis resolved heterogeneity (RR: 0.62, 95% CI: 0.33–1.17, <i>P</i> = 0.14, I² = 0%). NPWT also showed no significant benefit in preventing wound dehiscence (RR: 2.44, <i>P</i> = 0.35), seroma (RR: 0.87, <i>P</i> = 0.92), or reducing reintervention rates (RR: 0.69, <i>P</i> = 0.36). The length of hospital stay was comparable between groups (MD: -0.25 days, <i>P</i> = 0.80).</p> Conclusion <p>This meta-analysis suggests that NPWT does not significantly reduce wound complications, SSI, or LOS in CRC surgery.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Effect of negative pressure wound therapy on surgical wound outcomes in colorectal cancer surgery patients: a systematic review and meta-analysis

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年4月11日

查看全文
  • Mohamed Sherif Ali Ahmed,
  • Mostafa Ismail Mahmoud Hassan,
  • Ahmed Ibrahim,
  • Ahmed Lamey,
  • Mahmoud M. Elsayed,
  • Ahmed Elshaboury,
  • Mohamed Hamouda Elkasaby,
  • Ahmed Abdelrafee

摘要

Background

Surgical site infections (SSI) and wound complications are major concerns in colorectal cancer (CRC) surgery. Negative pressure wound therapy (NPWT) has been proposed to reduce these complications, but its efficacy specifically in CRC surgery remains uncertain. This meta-analysis evaluates the impact of NPWT on surgical wound outcomes compared to standard wound care in patients undergoing CRC surgery.

Methods

A systematic search of PubMed, Scopus, Web of Science, and Cochrane Library was conducted up to February 10, 2025, for studies comparing NPWT with standard wound care in CRC surgery patients. The primary outcome was total wound complications. Risk ratios (RR) and mean differences (MD) were pooled using a random-effects model, with heterogeneity assessed using I² statistics.

Results

Six studies involving 343 patients (NPWT: 171, control: 172) were included. NPWT did not significantly reduce total wound complications (RR: 0.67, 95% CI: 0.35–1.26, P = 0.21, I² = 66%). Similarly, no significant differences were found for SSI (RR: 0.80, 95% CI: 0.45–1.43, P = 0.45), even after sensitivity analysis resolved heterogeneity (RR: 0.62, 95% CI: 0.33–1.17, P = 0.14, I² = 0%). NPWT also showed no significant benefit in preventing wound dehiscence (RR: 2.44, P = 0.35), seroma (RR: 0.87, P = 0.92), or reducing reintervention rates (RR: 0.69, P = 0.36). The length of hospital stay was comparable between groups (MD: -0.25 days, P = 0.80).

Conclusion

This meta-analysis suggests that NPWT does not significantly reduce wound complications, SSI, or LOS in CRC surgery.