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Background <p>Peptic ulcer perforation remains a life-threatening surgical emergency associated with considerable postoperative mortality. Identifying reliable preoperative predictors is crucial for risk stratification. In this study, we aimed to investigate the predictive value of C-reactive protein, albumin/creatinine ratio, defect size, and selected demographic variables for 30-day mortality following surgical treatment of peptic ulcer perforation.</p> Methods <p>A retrospective analysis was conducted on 154 patients who underwent emergency surgery for peptic ulcer perforation. The association between 30-day postoperative mortality and C-reactive protein, albumin/creatinine ratio, defect size, as well as selected demographic variables was evaluated. Univariate and multivariate logistic regression analyses were performed. ROC analysis was used to determine optimal cutoff values. <i>p</i> &lt; 0.05 was considered statistically significant.</p> Results <p>The mean age of the patients was 56. 102 (66.2%) of the patients were male. The 30-day mortality rate in the study cohort was 16.9%. A CRP level greater than 88&#xa0;mg/L (<i>p</i> &lt; 0,001) and an albumin/creatinine ratio below 3.37 (<i>p</i> &lt; 0.001) were identified as independent predictors of mortality. While a defect size greater than 5&#xa0;mm was significant in univariate analysis, it did not retain significance in the multivariate model.</p> Conclusion <p>CRP and the albumin/creatinine ratio are easily accessible biomarkers that may support perioperative risk stratification in patients undergoing surgery for perforated peptic ulcer. Defect size alone may be insufficient to reliably reflect prognosis when systemic inflammatory markers are taken into account.</p>

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The role of biomarkers in predicting mortality in peptic ulcer perforation

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年1月28日

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  • Fırat Canlıkarakaya,
  • Serhat Ocaklı,
  • İbrahim Doğan,
  • Nurhak Cihangir Çınkıl,
  • Sabiha Nur Özmen,
  • Cengiz Ceylan

摘要

Background

Peptic ulcer perforation remains a life-threatening surgical emergency associated with considerable postoperative mortality. Identifying reliable preoperative predictors is crucial for risk stratification. In this study, we aimed to investigate the predictive value of C-reactive protein, albumin/creatinine ratio, defect size, and selected demographic variables for 30-day mortality following surgical treatment of peptic ulcer perforation.

Methods

A retrospective analysis was conducted on 154 patients who underwent emergency surgery for peptic ulcer perforation. The association between 30-day postoperative mortality and C-reactive protein, albumin/creatinine ratio, defect size, as well as selected demographic variables was evaluated. Univariate and multivariate logistic regression analyses were performed. ROC analysis was used to determine optimal cutoff values. p < 0.05 was considered statistically significant.

Results

The mean age of the patients was 56. 102 (66.2%) of the patients were male. The 30-day mortality rate in the study cohort was 16.9%. A CRP level greater than 88 mg/L (p < 0,001) and an albumin/creatinine ratio below 3.37 (p < 0.001) were identified as independent predictors of mortality. While a defect size greater than 5 mm was significant in univariate analysis, it did not retain significance in the multivariate model.

Conclusion

CRP and the albumin/creatinine ratio are easily accessible biomarkers that may support perioperative risk stratification in patients undergoing surgery for perforated peptic ulcer. Defect size alone may be insufficient to reliably reflect prognosis when systemic inflammatory markers are taken into account.