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Background <p>The preventive effect of oral steroid plus polyglycolic acid (PGA) sheet has not been reported until now.</p> Methods <p>Clinical and endoscopic characteristics were recorded in patients with oral steroid or PGA sheet plus oral steroid after esophageal endoscopic submucosal dissection (ESD). Propensity score matching was used to reduce selection bias. The endoscopic balloon dilation (EBD) times and stricture rates were compared.</p> Results <p>The PGA sheet plus oral steroid prophylaxis was reported higher stricture rate (38.7% vs. 37.5%) and refractory stricture rate (9.7% vs. 9.1%) than the oral steroid group. After propensity score matching,the stenosis rate was reduced under the PGA sheet use (38.7% vs 64.5%, p=0.042).In subgroup analysis, additional PGA sheet achieved a lower stricture rate than oral steroid alone in the patients with non-circumferential mucosal defect (23.5% vs 61.1%, p=0.025), but not for refractory stricture incidence (0.0% vs 11.1%, p=0.486). The hybrid treatment did not exhibit superior efficacy for patients with circumferential mucosal defects, whether for stricture (57.1% vs 69.2%) or refractory stricture (21.4% vs 38.5%). </p> Conclusions <p> The PGA sheet plus oral steroid is safe, and compared to oral steroid, the hybrid treatment significantly reduced the stricture rate.Further studies with larger sample sizes are warranted to investigate the potential of this hybrid treatment on preventing post-ESD esophageal stricture, especially in patients with circumferential mucosal defects.</p> Trial registration <p>Not applicable.</p>

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Efficacy of polyglycolic acid sheet plus oral steroid on the esophageal stricture after endoscopic submucosal dissection: a propensity score matched retrospective study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年1月7日

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  • Miaoxin Zhang,
  • Wei Tian,
  • Xinxia Feng,
  • Panpan Lu,
  • Qiang Ding,
  • Mei Liu

摘要

Background

The preventive effect of oral steroid plus polyglycolic acid (PGA) sheet has not been reported until now.

Methods

Clinical and endoscopic characteristics were recorded in patients with oral steroid or PGA sheet plus oral steroid after esophageal endoscopic submucosal dissection (ESD). Propensity score matching was used to reduce selection bias. The endoscopic balloon dilation (EBD) times and stricture rates were compared.

Results

The PGA sheet plus oral steroid prophylaxis was reported higher stricture rate (38.7% vs. 37.5%) and refractory stricture rate (9.7% vs. 9.1%) than the oral steroid group. After propensity score matching,the stenosis rate was reduced under the PGA sheet use (38.7% vs 64.5%, p=0.042).In subgroup analysis, additional PGA sheet achieved a lower stricture rate than oral steroid alone in the patients with non-circumferential mucosal defect (23.5% vs 61.1%, p=0.025), but not for refractory stricture incidence (0.0% vs 11.1%, p=0.486). The hybrid treatment did not exhibit superior efficacy for patients with circumferential mucosal defects, whether for stricture (57.1% vs 69.2%) or refractory stricture (21.4% vs 38.5%).

Conclusions

The PGA sheet plus oral steroid is safe, and compared to oral steroid, the hybrid treatment significantly reduced the stricture rate.Further studies with larger sample sizes are warranted to investigate the potential of this hybrid treatment on preventing post-ESD esophageal stricture, especially in patients with circumferential mucosal defects.

Trial registration

Not applicable.