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Background <p>Pineal region hemangioblastoma(PR-HB) is an exceptionally rare vascular tumor, often misdiagnosed due to overlap with more common pineal lesions. Accurate identification is essential for safe surgical management.</p> Case presentation <p>We report a 54-year-old woman presenting with acute dizziness, nausea, and vomiting. MRI revealed a vividly enhancing pineal mass with prominent flow voids causing obstructive hydrocephalus. The tumor was removed via a left paramedian supracerebellar infratentorial approach, achieving gross-total resection. Histopathology and immunohistochemistry confirmed hemangioblastoma (inhibin-α positive, PAX8 negative). The patient recovered uneventfully, and no recurrence was observed at 12-month follow-up.</p> Discussion <p>Although extremely rare, pineal hemangioblastoma should be considered in the differential diagnosis of hypervascular pineal masses. Review of previously published cases demonstrates consistent radiological features, diagnostic pitfalls, surgical considerations, and the importance of distinguishing hemangioblastoma from metastatic renal cell carcinoma.</p> Conclusion <p>Pineal hemangioblastoma is a surgically curable entity. Recognition of its imaging and immunohistochemical characteristics facilitates safe resection and accurate diagnosis.</p>

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Pineal region hemangioblastoma: a case report and literature review

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年12月15日

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  • Bo Tan,
  • Yuyuan Li,
  • Xingrong Zhang,
  • Bin Yang,
  • Yaohui Huang,
  • Xiaohong Yin

摘要

Background

Pineal region hemangioblastoma(PR-HB) is an exceptionally rare vascular tumor, often misdiagnosed due to overlap with more common pineal lesions. Accurate identification is essential for safe surgical management.

Case presentation

We report a 54-year-old woman presenting with acute dizziness, nausea, and vomiting. MRI revealed a vividly enhancing pineal mass with prominent flow voids causing obstructive hydrocephalus. The tumor was removed via a left paramedian supracerebellar infratentorial approach, achieving gross-total resection. Histopathology and immunohistochemistry confirmed hemangioblastoma (inhibin-α positive, PAX8 negative). The patient recovered uneventfully, and no recurrence was observed at 12-month follow-up.

Discussion

Although extremely rare, pineal hemangioblastoma should be considered in the differential diagnosis of hypervascular pineal masses. Review of previously published cases demonstrates consistent radiological features, diagnostic pitfalls, surgical considerations, and the importance of distinguishing hemangioblastoma from metastatic renal cell carcinoma.

Conclusion

Pineal hemangioblastoma is a surgically curable entity. Recognition of its imaging and immunohistochemical characteristics facilitates safe resection and accurate diagnosis.