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Background <p>Three-dimensional CT enables quantitative assessment of lobar and lung volumes after anatomical resection, yet how postoperative compensation pattern relates to operation type remains unclear.</p> Methods <p>In this single-center retrospective cohort (<i>n</i> = 124), preoperative and postoperative 3D-CT volumes were quantified. The primary outcome was postoperative change in lung volume relative to preoperative baseline (Vpost − Vpre, %). Multivariable models adjusted for age, sex, BMI, and smoking; p values were FDR-adjusted. We also compared measured versus predicted percentages derived from preoperative ipsilateral lung and target-lobe volumes.</p> Results <p>Overall, postoperative total lung volume decreased modestly, with larger ipsilateral loss than contralateral change. After adjustment, left-lower lobe resections showed a greater ipsilateral volume decrease after lobectomy than after segmentectomy (FDR-significant), whereas differences in other lobes were small or uncertain after multiplicity control. Measured versus predicted comparisons indicated partial compensation on the operated side and near-preservation on the contralateral side.</p> Conclusions <p>Findings highlight side-dependent compensation patterns and suggest that operation choice may influence ipsilateral volume loss in selected settings. Given the retrospective design and small surgical subgroups, these results are hypothesis-generating and warrant prospective validation and integration with oncologic considerations.</p>

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Residual lung volume changes after thoracoscopic lobectomy and segmentectomy based on 3D-CT: a retrospective preliminary validation study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年1月2日

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  • Shiyu Shen,
  • Minda Xu,
  • Yu Zhang,
  • Yuhui Gong,
  • Wei Feng,
  • Haifeng Xia,
  • Jianhong Pu,
  • Jialiang Liu,
  • Haitao Ma,
  • Haitao Huang

摘要

Background

Three-dimensional CT enables quantitative assessment of lobar and lung volumes after anatomical resection, yet how postoperative compensation pattern relates to operation type remains unclear.

Methods

In this single-center retrospective cohort (n = 124), preoperative and postoperative 3D-CT volumes were quantified. The primary outcome was postoperative change in lung volume relative to preoperative baseline (Vpost − Vpre, %). Multivariable models adjusted for age, sex, BMI, and smoking; p values were FDR-adjusted. We also compared measured versus predicted percentages derived from preoperative ipsilateral lung and target-lobe volumes.

Results

Overall, postoperative total lung volume decreased modestly, with larger ipsilateral loss than contralateral change. After adjustment, left-lower lobe resections showed a greater ipsilateral volume decrease after lobectomy than after segmentectomy (FDR-significant), whereas differences in other lobes were small or uncertain after multiplicity control. Measured versus predicted comparisons indicated partial compensation on the operated side and near-preservation on the contralateral side.

Conclusions

Findings highlight side-dependent compensation patterns and suggest that operation choice may influence ipsilateral volume loss in selected settings. Given the retrospective design and small surgical subgroups, these results are hypothesis-generating and warrant prospective validation and integration with oncologic considerations.