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Background <p>Splenectomy is a common procedure for cytoreductive surgery in ovarian cancer. Secondary infective endocarditis after splenectomy for malignancy has not been previously reported.</p> Case presentation <p>A 54-year-old female patient who underwent splenectomy for cytoreductive surgery of ovarian cancer had an elevated postoperative white blood cell (WBC) count and subsequent intestinal obstruction. Echocardiography revealed vegetation on the mitral valve leaflet, and next-generation sequencing identified <i>Gemella morbillorum</i> in the blood. Subsequently, she was diagnosed with infective endocarditis and ultimately died from septicemia.</p> Conclusion <p>Postsplenectomy secondary infective endocarditis warrants attention. This requires preoperative proper assessment of tolerance for surgical complications, recognizing the implications of an elevated WBC count after splenectomy, actively managing postoperative intestinal obstruction, and identifying opportunistic infections.</p>

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Infective endocarditis after splenectomy for ovarian cancer: a case report

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年11月27日

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  • Luxin Ye,
  • Xuening Wang,
  • Qian Zhao,
  • Xianzhong Cheng,
  • Yourong Chen,
  • Bifang Zhou,
  • Jin Liu,
  • Jing Ni,
  • Xiaoxiang Chen

摘要

Background

Splenectomy is a common procedure for cytoreductive surgery in ovarian cancer. Secondary infective endocarditis after splenectomy for malignancy has not been previously reported.

Case presentation

A 54-year-old female patient who underwent splenectomy for cytoreductive surgery of ovarian cancer had an elevated postoperative white blood cell (WBC) count and subsequent intestinal obstruction. Echocardiography revealed vegetation on the mitral valve leaflet, and next-generation sequencing identified Gemella morbillorum in the blood. Subsequently, she was diagnosed with infective endocarditis and ultimately died from septicemia.

Conclusion

Postsplenectomy secondary infective endocarditis warrants attention. This requires preoperative proper assessment of tolerance for surgical complications, recognizing the implications of an elevated WBC count after splenectomy, actively managing postoperative intestinal obstruction, and identifying opportunistic infections.