Objective <p>This study summarized our experience in treating arterial gastrointestinal bleeding with Glubran-2 glue embolization, and analyzed efficacy and safety of Punctate embolism and Flake Embolism.</p> Method <p>Clinical data collected between January 2009 and January 2021 from patients with arterial gastrointestinal bleeding treated with Glubran-2 glue were analyzed retrospectively. Subsequently, univariate analysis and binary logistic regression analysis were performed to examine the risk factors associated with clinical outcomes and 30-day postoperative mortality. Finally, according to the embolization methods, it is divided into Punctate embolism(<i>n</i>=37) and Flake embolism(n༝44), and the curative effects of the two groups of embolization methods are analyzed.</p> Result <p>For a total of 81 patients, the technical success rate was 100%, the clinical success rate was 71.6% (<i>n</i> = 58), and the 30-day mortality rate post-endovascular interventions was 13.6% (<i>n</i> = 11). In addition, there was a significant negative correlation between the volume of blood transfusion and clinical outcome (<i>P</i> &lt; 0.05), Furthermore, clinical outcome, coagulopathy, and heart rate were identified as independent risk factors for the 30-day mortality rate post-endovascular interventions. Finally, the clinical success rate (86.5%VS59.1%) of Punctate embolism is much higher than that of Flake embolism, and the mortality rate (5.4%VS20.5%) is obviously lower (<i>P</i> &lt; 0.05).</p> Conclusion <p>The findings of the study confirm that the use of Glubran-2 glue embolization offers a secure and effective treatment strategy for treating arterial gastrointestinal bleeding. The results suggest that punctate embolism may be associated with improved outcomes compared to flake embolism.</p>