Scholarlink

Background <p>Bariatric surgery can decrease cardiovascular risk because of its effects on atherosclerotic cardiovascular disease (ASCVD) risk factors such as dyslipidemia, diabetes mellitus, and hypertension. It has been hypothesized that lipoprotein biomarkers related to low-density lipoproteins (LDL) and high-density lipoproteins (HDL) as well as their subfractions and macrophage cholesterol efflux capacity (CEC) might be important in cardiovascular risk assessment.</p> Objective <p>The aim of this systematic review and meta-analysis was to evaluate the CEC of HDL as a negative risk factor for ASCVD in individuals with obesity following bariatric surgery.</p> Data source <p>PubMed, Scopus, Web of Science and Scholar were searched from inception to May, 2024.</p> Studies selection <p>Clinical studies that reported CEC data with a follow-up after bariatric surgery were eligible for meta-analysis.</p> Data extraction <p>Two independent reviewers extracted data and assessed the risk of bias.</p> Results <p>Among the 55 articles identified, 8 studies measuring cholesterol efflux capacity (CEC) after bariatric surgery were analyzed. Four studies indicated a nonsignificant increase in total CEC after Roux-en-Y gastric bypass (RYGB) or sleeve gastrectomy (SG) (SMD: 0.361, <i>p</i> = 0.256). Five studies showed a significant reduction in ABCA1-dependent CEC after the surgery (SMD: -1.044, 95% CI: -1.916, -0.173, <i>p</i> = 0.019). In contrast, five studies reported a significant increase in ABCA1-independent CEC (SMD: 0.932, 95% CI: 0.142, 1.722, <i>p</i> = 0.021). Subgroup analyses showed that total CEC varied by type of surgery, with significant increases for SG (SMD: 0.748, <i>p</i> &lt; 0.001) but not for RYGB (SMD: -0.341, <i>p</i> = 0.650). ABCA1-dependent CEC decreased significantly after RYGB (SMD: -1.545, <i>p</i> = 0.015), while no significant changes were observed for ABCA1-independent CEC after both types of surgery.</p> Conclusion <p>Bariatric surgery, particularly SG, is associated with clinically significant increase in total post-surgery CEC which might be beneficial concerning the ASCVD risk.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Improvements in cholesterol efflux capacity of HDL after bariatric surgery in patients with obesity: a meta-analysis

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年10月10日

查看全文
  • Tannaz Jamialahmadi,
  • Elaheh Mirhadi,
  • Željko Reiner,
  • Saheem Ahmad,
  • Bodor Bin Sheeha,
  • Safia Obaidur Raba,
  • Wael Almahmeed,
  • Amirhossein Sahebkar

摘要

Background

Bariatric surgery can decrease cardiovascular risk because of its effects on atherosclerotic cardiovascular disease (ASCVD) risk factors such as dyslipidemia, diabetes mellitus, and hypertension. It has been hypothesized that lipoprotein biomarkers related to low-density lipoproteins (LDL) and high-density lipoproteins (HDL) as well as their subfractions and macrophage cholesterol efflux capacity (CEC) might be important in cardiovascular risk assessment.

Objective

The aim of this systematic review and meta-analysis was to evaluate the CEC of HDL as a negative risk factor for ASCVD in individuals with obesity following bariatric surgery.

Data source

PubMed, Scopus, Web of Science and Scholar were searched from inception to May, 2024.

Studies selection

Clinical studies that reported CEC data with a follow-up after bariatric surgery were eligible for meta-analysis.

Data extraction

Two independent reviewers extracted data and assessed the risk of bias.

Results

Among the 55 articles identified, 8 studies measuring cholesterol efflux capacity (CEC) after bariatric surgery were analyzed. Four studies indicated a nonsignificant increase in total CEC after Roux-en-Y gastric bypass (RYGB) or sleeve gastrectomy (SG) (SMD: 0.361, p = 0.256). Five studies showed a significant reduction in ABCA1-dependent CEC after the surgery (SMD: -1.044, 95% CI: -1.916, -0.173, p = 0.019). In contrast, five studies reported a significant increase in ABCA1-independent CEC (SMD: 0.932, 95% CI: 0.142, 1.722, p = 0.021). Subgroup analyses showed that total CEC varied by type of surgery, with significant increases for SG (SMD: 0.748, p < 0.001) but not for RYGB (SMD: -0.341, p = 0.650). ABCA1-dependent CEC decreased significantly after RYGB (SMD: -1.545, p = 0.015), while no significant changes were observed for ABCA1-independent CEC after both types of surgery.

Conclusion

Bariatric surgery, particularly SG, is associated with clinically significant increase in total post-surgery CEC which might be beneficial concerning the ASCVD risk.