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Purpose/Introduction <p>Historically, hypertension (HTN) and osteoporosis, as indicated by bone mineral density (BMD), were viewed as distinct conditions. However, current understanding highlights the role of vascular inflammation and immune cell activation in both diseases. The exact relationship between HTN and BMD, however, remains poorly defined.</p> Methods <p>Participants from the MESA study, both with and without hypertension (defined as systolic blood pressure ≥ 140 mmHg and/or diastolic blood pressure ≥ 90 mmHg, or the use of antihypertensive drugs), underwent thoracic spine BMD measurement using non-contrast CT chest. Linear regression was used to assess the relationship between BMD and HTN. BMD was also categorized by T-scores (normal, osteopenia, osteoporosis) and analyzed using proportional odds logistic regression. The models were adjusted for variables such as age, gender, race/ethnicity, BMI, and osteoporosis medication use to assess these associations.</p> Results <p>Among the 6,814 participants, those with hypertension (HTN) were older and more likely to be Black and female. Osteoporosis was more prevalent among hypertensive individuals (30% vs. 23%), with a lower mean BMD by 6.23&#xa0;mg/cc in unadjusted analysis (<i>p</i> &lt; 0.001). However, after adjusting for confounders, the association between HTN and BMD was not significant (<i>p</i> = 0.687). In adjusted models, Black, Chinese, and Hispanic participants had significantly higher BMD compared to White participants. Additionally, higher BMI was associated with increased BMD, while older age was associated with lower BMD.</p> Conclusion <p>The findings indicate that hypertension does not have an independent association with BMD.</p>

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The relationship between hypertension and thoracic spine bone mineral density: the Multi-Ethnic Study of Atherosclerosis (MESA)

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月2日

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  • Ahmed K Ghanem,
  • Venkat S. Manubolu,
  • April Kinninger,
  • Robyn L. McClelland,
  • Jaewon Lim,
  • Denise Javier,
  • Khadije Ahmad,
  • Hossein Hamidi,
  • Marziyeh Bagheri,
  • Mina Deljavanghodrati,
  • Sion K Roy,
  • Matthew J Budoff

摘要

Purpose/Introduction

Historically, hypertension (HTN) and osteoporosis, as indicated by bone mineral density (BMD), were viewed as distinct conditions. However, current understanding highlights the role of vascular inflammation and immune cell activation in both diseases. The exact relationship between HTN and BMD, however, remains poorly defined.

Methods

Participants from the MESA study, both with and without hypertension (defined as systolic blood pressure ≥ 140 mmHg and/or diastolic blood pressure ≥ 90 mmHg, or the use of antihypertensive drugs), underwent thoracic spine BMD measurement using non-contrast CT chest. Linear regression was used to assess the relationship between BMD and HTN. BMD was also categorized by T-scores (normal, osteopenia, osteoporosis) and analyzed using proportional odds logistic regression. The models were adjusted for variables such as age, gender, race/ethnicity, BMI, and osteoporosis medication use to assess these associations.

Results

Among the 6,814 participants, those with hypertension (HTN) were older and more likely to be Black and female. Osteoporosis was more prevalent among hypertensive individuals (30% vs. 23%), with a lower mean BMD by 6.23 mg/cc in unadjusted analysis (p < 0.001). However, after adjusting for confounders, the association between HTN and BMD was not significant (p = 0.687). In adjusted models, Black, Chinese, and Hispanic participants had significantly higher BMD compared to White participants. Additionally, higher BMI was associated with increased BMD, while older age was associated with lower BMD.

Conclusion

The findings indicate that hypertension does not have an independent association with BMD.