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Background <p>Chronic non-specific low back pain (CNLBP) has become a major public health problem that needs to be addressed. This cross-sectional study aimed to compare the activation of contingent negative variation (CNV) and anticipatory postural adjustments (APAs) in patients with CNLBP with those in healthy subjects, and to correlate them with clinical symptoms.</p> Methods <p>This trial was registered on October 1, 2022. And this study included 21 patients with CNLBP and 20 healthy controls. Demographic data and assessment of APAs were collected for both groups. Visual Analog Scale (VAS), Oswestry Disability Index (ODI) and Fear Avoidance Belief Questionnaire (FABQ) were additionally collected from the CNLBP group. The activation time and intensity of core muscle group were recorded during the anticipatory postural conditioning task (rapid arm lift) using surface electromyography (sEMG), and the CNV amplitude at the Cz point during the motor preparation period was captured using electroencephalography (EEG). Independent samples t-tests and chi-square tests were used to access between-group differences, while Pearson’s correlation analysis was used to examine central-peripheral index associations.</p> Results <p>During the APAs task, the CNLBP group showed delayed activation of the left transversus abdominis (<i>p</i> &lt; 0.001) and left erector spinae (<i>p =</i> 0.046), reduced activation intensity of the right erector spinae (<i>p</i> = 0.02) and left multifidus (<i>p</i> = 0.03), and a significant reduction in the CNV amplitude compared to the healthy group (<i>p</i> = 0.01). Correlation analysis showed that CNV amplitude was negatively correlated with the time of APAs in the left transversus abdominis muscle (<i>r</i> = -0.58, <i>p</i> = 0.02), VAS score (<i>r</i> = -0.53, <i>p</i> = 0.04), and FABQ score (<i>r</i> = -0.67, <i>p</i> = 0.01).</p> Conclusion <p>This study linked reduced CNV amplitude to delayed APAs activation in CNLBP patients. Deficits in the central processes of motor preparation may contribute to impaired anticipatory postural control in patients with CNLBP.</p>

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Correlation study between brain activation levels and postural control performance in patients with chronic non-specific low back pain

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年3月3日

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  • Wenqing Liu,
  • Jiahui Peng,
  • Liping Zhao,
  • Xue Cheng,
  • Yan Leng,
  • Jiajia Yang,
  • Qiuhua Yu,
  • Chuhuai Wang

摘要

Background

Chronic non-specific low back pain (CNLBP) has become a major public health problem that needs to be addressed. This cross-sectional study aimed to compare the activation of contingent negative variation (CNV) and anticipatory postural adjustments (APAs) in patients with CNLBP with those in healthy subjects, and to correlate them with clinical symptoms.

Methods

This trial was registered on October 1, 2022. And this study included 21 patients with CNLBP and 20 healthy controls. Demographic data and assessment of APAs were collected for both groups. Visual Analog Scale (VAS), Oswestry Disability Index (ODI) and Fear Avoidance Belief Questionnaire (FABQ) were additionally collected from the CNLBP group. The activation time and intensity of core muscle group were recorded during the anticipatory postural conditioning task (rapid arm lift) using surface electromyography (sEMG), and the CNV amplitude at the Cz point during the motor preparation period was captured using electroencephalography (EEG). Independent samples t-tests and chi-square tests were used to access between-group differences, while Pearson’s correlation analysis was used to examine central-peripheral index associations.

Results

During the APAs task, the CNLBP group showed delayed activation of the left transversus abdominis (p < 0.001) and left erector spinae (p = 0.046), reduced activation intensity of the right erector spinae (p = 0.02) and left multifidus (p = 0.03), and a significant reduction in the CNV amplitude compared to the healthy group (p = 0.01). Correlation analysis showed that CNV amplitude was negatively correlated with the time of APAs in the left transversus abdominis muscle (r = -0.58, p = 0.02), VAS score (r = -0.53, p = 0.04), and FABQ score (r = -0.67, p = 0.01).

Conclusion

This study linked reduced CNV amplitude to delayed APAs activation in CNLBP patients. Deficits in the central processes of motor preparation may contribute to impaired anticipatory postural control in patients with CNLBP.