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Background <p>Osteoporosis is often undiagnosed until fractures occur. A parental history of proximal femur fracture is an independent risk factor for osteoporosis in the next generation. This study evaluated whether adult children of affected patients represent a suitable target group for early screening.</p> Methods <p>Over 12 months, patients aged ≥ 70 years with low-energy proximal femur fractures were enrolled. Their adult children were invited to participate. Medical history, laboratory testing, and fracture risk assessment using FRAX<sup>®</sup> were performed. Treatment thresholds followed AACE guidelines (≥ 3% proximal femur fracture or ≥ 20% major osteoporotic fracture [MOF] risk).</p> Results <p>Of 189 patients screened, 183 were eligible (mean age 83 years). Sixty adult children participated (mean age 62 years). One had a prior osteoporosis diagnosis; nine reported previous MOF. Based on FRAX<sup>®</sup>, 40% exceeded treatment thresholds. Vitamin D insufficiency was present in 85%, with supplementation associated with higher serum concentrations.</p> Conclusions <p>Adult children of patients with proximal femur fractures represent a high-risk group for osteoporosis. Nearly half met treatment thresholds, supporting targeted screening in individuals ≥ 50 years when a parent sustains such a fracture. This approach may enable earlier diagnosis and prevention of osteoporotic fractures.</p>

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Early detection of osteoporosis in adult children of patients with proximal femur fractures: a real-world screening study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年12月2日

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  • Steffi S.I. Falk,
  • Swenja Block,
  • Thomas Mittlmeier,
  • Hans-Christof Schober

摘要

Background

Osteoporosis is often undiagnosed until fractures occur. A parental history of proximal femur fracture is an independent risk factor for osteoporosis in the next generation. This study evaluated whether adult children of affected patients represent a suitable target group for early screening.

Methods

Over 12 months, patients aged ≥ 70 years with low-energy proximal femur fractures were enrolled. Their adult children were invited to participate. Medical history, laboratory testing, and fracture risk assessment using FRAX® were performed. Treatment thresholds followed AACE guidelines (≥ 3% proximal femur fracture or ≥ 20% major osteoporotic fracture [MOF] risk).

Results

Of 189 patients screened, 183 were eligible (mean age 83 years). Sixty adult children participated (mean age 62 years). One had a prior osteoporosis diagnosis; nine reported previous MOF. Based on FRAX®, 40% exceeded treatment thresholds. Vitamin D insufficiency was present in 85%, with supplementation associated with higher serum concentrations.

Conclusions

Adult children of patients with proximal femur fractures represent a high-risk group for osteoporosis. Nearly half met treatment thresholds, supporting targeted screening in individuals ≥ 50 years when a parent sustains such a fracture. This approach may enable earlier diagnosis and prevention of osteoporotic fractures.