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Background <p>Osteoarthritis (OA) is closely linked to cardiovascular diseases, mainly afflicting older adults. Our study aims to explore the association between Life’s Essential 8 (LE8), a newly developed measurement of cardiovascular health (CVH), and OA in the middle-aged and elderly population.</p> Methods <p>Our study utilized data from the National Health and Nutrition Examination Survey 2007–2018. OA was ascertained by self-reported data from questionnaires. The overall LE8 score is calculated as the mean of 8 individual metric scores ranging from 0 to 100 and is categorized into three CVH levels: low (0–49), moderate (50–79), and high (80–100). Multivariate logistic and restricted cubic spline regression models were performed to explore the associations between CVH and OA. Subgroup and sensitivity analyses were conducted to test the robustness of main results.</p> Results <p>Our study included 10,231 participants aged ≥ 40 years from NHANES. The total age-adjusted prevalence of OA was 22.4%. After adjusting for the potential covariates, the adjusted odds ratio (AOR) of OA was significantly lower in participants with a moderate level (AOR = 0.687, 95% CI: 0.531, 0.889) or high CVH level (AOR = 0.430, 95% CI: 0.326, 0.567) compared to those with a low CVH level. Similar trends in the associations of the health behavior score and health factor score with OA were also observed.</p> Conclusions <p>LE8-evaluated CVH levels were inversely associated with OA risks in the middle-aged and elderly U.S. population, indicating that maintaining the optimal CVH level may potentially contribute to the management of OA risks.</p>

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Relationship between cardiovascular health and osteoarthritis in middle-aged and elderly U.S. population: a cross-sectional NHANES study

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  • 发表日期：

    2025年5月29日

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  • Dui Mou,
  • Yuhang Liu,
  • Siyao Gao,
  • Peng Zhao

摘要

Background

Osteoarthritis (OA) is closely linked to cardiovascular diseases, mainly afflicting older adults. Our study aims to explore the association between Life’s Essential 8 (LE8), a newly developed measurement of cardiovascular health (CVH), and OA in the middle-aged and elderly population.

Methods

Our study utilized data from the National Health and Nutrition Examination Survey 2007–2018. OA was ascertained by self-reported data from questionnaires. The overall LE8 score is calculated as the mean of 8 individual metric scores ranging from 0 to 100 and is categorized into three CVH levels: low (0–49), moderate (50–79), and high (80–100). Multivariate logistic and restricted cubic spline regression models were performed to explore the associations between CVH and OA. Subgroup and sensitivity analyses were conducted to test the robustness of main results.

Results

Our study included 10,231 participants aged ≥ 40 years from NHANES. The total age-adjusted prevalence of OA was 22.4%. After adjusting for the potential covariates, the adjusted odds ratio (AOR) of OA was significantly lower in participants with a moderate level (AOR = 0.687, 95% CI: 0.531, 0.889) or high CVH level (AOR = 0.430, 95% CI: 0.326, 0.567) compared to those with a low CVH level. Similar trends in the associations of the health behavior score and health factor score with OA were also observed.

Conclusions

LE8-evaluated CVH levels were inversely associated with OA risks in the middle-aged and elderly U.S. population, indicating that maintaining the optimal CVH level may potentially contribute to the management of OA risks.