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Background <p>Chronic obstructive pulmonary disease (COPD) is a heterogeneous condition with multiple etiologies. We evaluated whether clinical characteristics differ according to COPD etiology.</p> Methods <p>Patients with infection as the sole etiology were classified as the infection-related group (COPD-I, Group I), whereas those with any smoking-related etiology were assigned to the smoking-related group (COPD-C, Group C).</p> Results <p>Of 873 patients included, 41 were classified as Group I and 832 as Group C. A significantly higher proportion of patients in Group I had a blood eosinophil count &lt; 100 cells/µL compared to Group C (44.4% vs. 27.8%; <i>p</i> = 0.031). The inhaled corticosteroid (ICS) prescription rate was lower in Group I compared to Group C (25.7% vs. 41.5%; <i>p</i> = 0.063). Multivariable logistic regression confirmed that Group I was independently associated with a lower likelihood of ICS use (<i>p</i> = 0.018). In addition, Group I exhibited a significantly higher residual volume to total lung capacity ratio (48.88% vs. 43.28%; <i>p</i> = 0.030), indicating greater air trapping and small airway involvement.</p> Conclusions <p>These findings support the notion that infection-related COPD (COPD-I) represents a clinically distinct phenotype.</p>

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Blood eosinophil count and clinical characteristics according to etiology in chronic obstructive pulmonary disease

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年6月3日

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  • Jeong Hyeon Seong,
  • Hee-Young Yoon,
  • Ye Jin Lee,
  • Hyonsoo Joo,
  • Joo Hun Park,
  • Seong Yong Lim,
  • Sang Yeub Lee,
  • Hyoung Kyu Yoon,
  • Kwang Ha Yoo,
  • Chin Kook Rhee

摘要

Background

Chronic obstructive pulmonary disease (COPD) is a heterogeneous condition with multiple etiologies. We evaluated whether clinical characteristics differ according to COPD etiology.

Methods

Patients with infection as the sole etiology were classified as the infection-related group (COPD-I, Group I), whereas those with any smoking-related etiology were assigned to the smoking-related group (COPD-C, Group C).

Results

Of 873 patients included, 41 were classified as Group I and 832 as Group C. A significantly higher proportion of patients in Group I had a blood eosinophil count < 100 cells/µL compared to Group C (44.4% vs. 27.8%; p = 0.031). The inhaled corticosteroid (ICS) prescription rate was lower in Group I compared to Group C (25.7% vs. 41.5%; p = 0.063). Multivariable logistic regression confirmed that Group I was independently associated with a lower likelihood of ICS use (p = 0.018). In addition, Group I exhibited a significantly higher residual volume to total lung capacity ratio (48.88% vs. 43.28%; p = 0.030), indicating greater air trapping and small airway involvement.

Conclusions

These findings support the notion that infection-related COPD (COPD-I) represents a clinically distinct phenotype.