Scholarlink

Background and aim <p>Short-chain fatty acids (SCFAs) are metabolites largely produced by the gut microbiota, except for formate, which is also produced by the host. SCFAs may influence COPD development by modulating the immune system. This study examined the relationships between circulating SCFA concentrations and COPD and COPD phenotypes.</p> Methods <p>We report findings from a single-centre observational study with 130 patients with COPD and 103 controls. Eight SCFAs (formate, acetate, propionate, butyrate, isobutyrate, valerate, isovalerate and α-methylbutyrate) were quantified in plasma using isotope-labelled gas chromatography-tandem mass spectrometry. Associations between SCFAs, COPD status, and COPD phenotypes (severely obstructive COPD, emphysema, eosinophilic COPD, frequent exacerbations, and symptom burden) were evaluated using multivariable regression analyses adjusted for age, sex, smoking, and body composition.</p> Results <p>Plasma formate concentrations were inversely associated with COPD status (adjusted OR 0.33; 95% CI 0.15 to 0.66; <i>p</i> = 0.004). Propionate and isobutyrate concentrations were inversely associated with severely obstructive COPD (adjusted ORs 0.46; 95% CI 0.24 to 0.86; <i>p</i> = 0.018, and 0.33; 95% CI 0.14 to 0.75; <i>p</i> = 0.012, respectively). Propionate concentrations were also inversely associated with frequent exacerbations of COPD (adjusted OR 0.23; 95% CI 0.07 to 0.62; <i>p</i> = 0.007). Isovalerate was positively associated with symptom burden (CAT score) (estimate 1.76; 95% CI 0.20 to 3.32; <i>p</i> = 0.027). No consistent associations were observed for emphysema or eosinophilic COPD.</p> Conclusions <p>SCFA formate was inversely related to COPD. Several SCFAs were associated with specific COPD phenotypes. Future studies should investigate the underlying mechanisms linking SCFAs to COPD and include the often-overlooked formate, while acknowledging formate’s dual origin.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Plasma short-chain fatty acids are associated with COPD and COPD phenotypes

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年5月16日

查看全文
  • Anders Ørskov Rotevatn,
  • Tomas Mikal Eagan,
  • Adrian McCann,
  • Johnny Laupsa-Borge,
  • Solveig Tangedal,
  • Gunnar Reksten Husebø,
  • Rune Nielsen

摘要

Background and aim

Short-chain fatty acids (SCFAs) are metabolites largely produced by the gut microbiota, except for formate, which is also produced by the host. SCFAs may influence COPD development by modulating the immune system. This study examined the relationships between circulating SCFA concentrations and COPD and COPD phenotypes.

Methods

We report findings from a single-centre observational study with 130 patients with COPD and 103 controls. Eight SCFAs (formate, acetate, propionate, butyrate, isobutyrate, valerate, isovalerate and α-methylbutyrate) were quantified in plasma using isotope-labelled gas chromatography-tandem mass spectrometry. Associations between SCFAs, COPD status, and COPD phenotypes (severely obstructive COPD, emphysema, eosinophilic COPD, frequent exacerbations, and symptom burden) were evaluated using multivariable regression analyses adjusted for age, sex, smoking, and body composition.

Results

Plasma formate concentrations were inversely associated with COPD status (adjusted OR 0.33; 95% CI 0.15 to 0.66; p = 0.004). Propionate and isobutyrate concentrations were inversely associated with severely obstructive COPD (adjusted ORs 0.46; 95% CI 0.24 to 0.86; p = 0.018, and 0.33; 95% CI 0.14 to 0.75; p = 0.012, respectively). Propionate concentrations were also inversely associated with frequent exacerbations of COPD (adjusted OR 0.23; 95% CI 0.07 to 0.62; p = 0.007). Isovalerate was positively associated with symptom burden (CAT score) (estimate 1.76; 95% CI 0.20 to 3.32; p = 0.027). No consistent associations were observed for emphysema or eosinophilic COPD.

Conclusions

SCFA formate was inversely related to COPD. Several SCFAs were associated with specific COPD phenotypes. Future studies should investigate the underlying mechanisms linking SCFAs to COPD and include the often-overlooked formate, while acknowledging formate’s dual origin.