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Background <p>Pulmonary mucormycosis is a rapidly progressive and often fatal invasive fungal infection typically associated with immunocompromised states. However, its emergence in immunocompetent individuals is increasingly reported. This case describes an unusual presentation of pulmonary mucormycosis in an immunocompetent adult complicated by arterial embolism, a rare and life-threatening vascular manifestation.</p> Case presentation <p>We report the case of an immunocompetent adult patient presenting with persistent respiratory symptoms and radiological abnormalities. Despite the absence of conventional risk factors, the diagnosis was challenging due to nonspecific clinical features. The clinical course was further complicated by the development of an arterial embolism. The pathogen was successfully identified through metagenomic next-generation sequencing (mNGS), highlighting the utility of molecular diagnostic platforms for early detection in atypical hosts. The patient’s management required a combination of targeted antifungal therapy and intervention for the vascular complication.</p> Conclusions <p>This case underscores the shifting epidemiology of mucormycosis and the necessity of maintaining a high index of clinical suspicion even in patients without apparent immunodeficiency. It emphasizes the critical role of advanced diagnostic tools like mNGS in reducing delays in intervention for a disease with mortality rates exceeding 30%–50%. Further research is required to standardize diagnostic algorithms and management strategies for pulmonary mucormycosis in immunocompetent populations.</p>

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When cough leads to infarction: systemic arterial embolism as a sentinel complication of insidious pulmonary mucormycosis in an immunocompetent patient

  • 期刊论文

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  • 发表日期：

    2026年3月14日

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  • Xiuying Ma,
  • Ruyi Zhang,
  • Lili Zuo,
  • Xiao Liang,
  • Jiawei Geng,
  • Yilan Xia

摘要

Background

Pulmonary mucormycosis is a rapidly progressive and often fatal invasive fungal infection typically associated with immunocompromised states. However, its emergence in immunocompetent individuals is increasingly reported. This case describes an unusual presentation of pulmonary mucormycosis in an immunocompetent adult complicated by arterial embolism, a rare and life-threatening vascular manifestation.

Case presentation

We report the case of an immunocompetent adult patient presenting with persistent respiratory symptoms and radiological abnormalities. Despite the absence of conventional risk factors, the diagnosis was challenging due to nonspecific clinical features. The clinical course was further complicated by the development of an arterial embolism. The pathogen was successfully identified through metagenomic next-generation sequencing (mNGS), highlighting the utility of molecular diagnostic platforms for early detection in atypical hosts. The patient’s management required a combination of targeted antifungal therapy and intervention for the vascular complication.

Conclusions

This case underscores the shifting epidemiology of mucormycosis and the necessity of maintaining a high index of clinical suspicion even in patients without apparent immunodeficiency. It emphasizes the critical role of advanced diagnostic tools like mNGS in reducing delays in intervention for a disease with mortality rates exceeding 30%–50%. Further research is required to standardize diagnostic algorithms and management strategies for pulmonary mucormycosis in immunocompetent populations.