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Background <p><i>Scedosporium apiospermum</i> is a highly aggressive opportunistic pathogen, widely distributed in natural environments. Infections predominantly occur in immunocompromised individuals but may also affect immunocompetent individuals with predisposing factors such as trauma, drowning, exposure to contaminated water, diabetes, or malnutrition.</p> Case presentation <p>In the reported case, morphological abnormalities were initially identified in bronchoalveolar lavage fluid (BALF). Subsequent microbial culture identification and metagenomic next-generation sequencing (mNGS) confirmed a mixed infection involving <i>S. apiospermum</i>.</p> Conclusions <p>This case highlights the importance of improving laboratory personnel’s morphological recognition of <i>S. apiospermum</i> in routine examinations. The combined use of multiple diagnostic methods enhances detection rates, shortens the time to identification, ensures timely and effective treatment for patients, and ultimately reduces mortality.</p>

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Case Report: diagnosis of mixed Scedosporium apiospermum infection assisted by bronchoalveolar lavage fluid morphology

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年3月11日

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  • Yuli Zhou,
  • Daojun Yu,
  • Shu Li,
  • Senlin Ruan,
  • Jun Ye,
  • Danxia Zhou,
  • Qiong Chen,
  • Juan Jin,
  • Kerui Song

摘要

Background

Scedosporium apiospermum is a highly aggressive opportunistic pathogen, widely distributed in natural environments. Infections predominantly occur in immunocompromised individuals but may also affect immunocompetent individuals with predisposing factors such as trauma, drowning, exposure to contaminated water, diabetes, or malnutrition.

Case presentation

In the reported case, morphological abnormalities were initially identified in bronchoalveolar lavage fluid (BALF). Subsequent microbial culture identification and metagenomic next-generation sequencing (mNGS) confirmed a mixed infection involving S. apiospermum.

Conclusions

This case highlights the importance of improving laboratory personnel’s morphological recognition of S. apiospermum in routine examinations. The combined use of multiple diagnostic methods enhances detection rates, shortens the time to identification, ensures timely and effective treatment for patients, and ultimately reduces mortality.